86815-10-3

Basic information

• Product Name: 2-(2-OXO-PYRROLIDIN-1-YL)-BUTYRIC ACID ETHYL ESTER
• Synonyms: 2-(2-OXO-PYRROLIDIN-1-YL)-BUTYRIC ACID ETHYL ESTER;EtiracetaM Carboxylic Acid Ethyl Ester
• CAS NO: 86815-10-3
• Molecular Formula: C₁₀H₁₇NO₃
• Molecular Weight: 199.25
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;Heterocycles, Neurochemicals, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 86815-10-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-(2-OXO-PYRROLIDIN-1-YL)-BUTYRIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-OXO-PYRROLIDIN-1-YL)-BUTYRIC ACID ETHYL ESTER(86815-10-3)
• EPA Substance Registry System: 2-(2-OXO-PYRROLIDIN-1-YL)-BUTYRIC ACID ETHYL ESTER(86815-10-3)

Safety Data

• Hazardous Substances Data: 86815-10-3(Hazardous Substances Data)

Usage

Chemical Properties

Brown Oil

Upstream product

• 64-17-5 ethanol 
• 67118-31-4 α-ethyl-2-oxo-1-pyrrolidineacetic acid, 
• 14468-90-7 N-trimethylsilyl-pyrrolidin-2-one 
• 533-68-6 2-bromobutyric acid ethyl ester 
• 616-45-5 2-pyrrolidinon 

Downstream Products

• 102767-28-2 levetiracetam 
• 102849-49-0 (2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid 
• 102916-46-1 (S)-α-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-α-methylbenzylamine salt 
• 67118-31-4 α-ethyl-2-oxo-1-pyrrolidineacetic acid, 

Relevant articles and documents

Preparation method of levetiracetam intermediate

The invention relates to a preparation method of alpha-ethyl-2-oxo-1-pyrrolidine acetate. Particularly, by optimizing a post-treatment process, the reaction yield and the product purity are remarkably improved.

REACTIONS OF N-SILYLATED LACTAMS WITH α-BROMO CARBOXYLATES

The reactions of N-trimethylsilyl lactams with α-bromo carboxylates proceeds in two directions: the N-alkylation of the lactams, and elimination with the formation of α,β-unsaturated carboxylic esters.The proportion between the two processes depends on the structure of the initial compounds.