864073-42-7 Usage
Description
12-AMino Minocycline, also known as Minocycline impurity, is a derivative of the antibiotic Minocycline (M344800). It possesses unique chemical properties that differentiate it from the parent compound, making it a valuable component in the development of specific pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
12-AMino Minocycline is used as a precursor in the synthesis of calpain inhibitors for various therapeutic applications. Calpain inhibitors are essential in the treatment of several diseases, including neurodegenerative disorders and muscular dystrophy, by modulating the activity of calpain enzymes involved in these conditions. The presence of 12-AMino Minocycline in the synthesis process contributes to the development of more effective and targeted inhibitors, enhancing their therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 864073-42-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,4,0,7 and 3 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 864073-42:
(8*8)+(7*6)+(6*4)+(5*0)+(4*7)+(3*3)+(2*4)+(1*2)=177
177 % 10 = 7
So 864073-42-7 is a valid CAS Registry Number.
864073-42-7Relevant articles and documents
TETRACYCLINES AND THEIR USE AS CALPAIN INHIBITORS
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Page/Page column 60-61, (2010/02/13)
Tetracyclines are useful as calpain inhibitors, particularly inhibitors of calpain I and II, as demonstrated in enzymatic assays as well as at the cellular and animal levels. Tetracyclines may be used in the treatment of a wide range of conditions implicated by or associated with calpain activity or activation, including cellular protection from apoptosis and necrosis, particularly n eu ro protection, prevention of cell motility (e.g. anti-metastasis of cancer) and treatment of certain infectious diseases (e.g. malaria and AIDS). Some tetracyclines are particularly useful as calpain inhibitors since they are also antioxidants, oxidative stress often being associated with conditions where calpain is activated.