860530-20-7Relevant articles and documents
Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents
Lang, Xuliang,Li, Lulu,Chen, Yuzong,Sun, Qinsheng,Wu, Qin,Liu, Feng,Tan, Chunyan,Liu, Hongxia,Gao, Chunmei,Jiang, Yuyang
supporting information, p. 4170 - 4177 (2013/07/27)
Acridine derivatives have been explored as DNA-binding anticancer agents. Some derivatives show undesired pharmacokinetic properties and new derivatives need to be explored. In this work, a series of novel acridine analogues were synthesized by modifying previously unexplored linkers between the acridine and benzene groups and their antiproliferative activity and the DNA-binding ability were evaluated. Among these derivatives, compound 5c demonstrated DNA-binding capability and topoisomerase I inhibitory activity. In K562 cell lines, 5c induced apoptosis through mitochondria-dependent intrinsic pathways. These data suggested that compound 5c and other acridine derivatives with modified linkers between the acridine and benzene groups might be potent DNA-binding agents.
