85260-51-1

Basic information

• Product Name: 2-Thiazolidinethione, 3-(1-oxopropyl)-
• Synonyms: 3-Propionylthiazolidine-2-thione;3-(1-Oxopropyl)-2-thiazolidinethione;1-(2-Thioxo-3-thiazolidinyl)-1-propanone;1-(2-Thioxo-thiazolidin-3-yl)-propan-1-one
• CAS NO: 85260-51-1
• Molecular Formula: C₆H₉NOS₂
• Molecular Weight: 175.27
• Product Categories: chemical additive;pharmaceutical intermediate
• Mol File: 85260-51-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 264℃
• Flash Point: 113℃
• Appearance: /
• Density: 1.32
• CAS DataBase Reference: 2-Thiazolidinethione, 3-(1-oxopropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiazolidinethione, 3-(1-oxopropyl)-(85260-51-1)
• EPA Substance Registry System: 2-Thiazolidinethione, 3-(1-oxopropyl)-(85260-51-1)

Safety Data

• Hazardous Substances Data: 85260-51-1(Hazardous Substances Data)

Usage

Uses

thiazolidin e thione pharmaceutical intermediate

Upstream product

• 134469-06-0 thiazolidine-2-thione 
• 802294-64-0 propionic acid 
• 123-62-6 propionic acid anhydride 
• 79-03-8 propionyl chloride 

Downstream Products

• 85260-56-6 threo-3-(3-hydroxy-2-methyl-5-phenylpentanoyl)thiazolidine-2-thione 
• 85260-56-6 erythro-3-(3-hydroxy-2-methyl-5-phenylpentanoyl)thiazolidine-2-thione 
• 105-37-3 Ethyl propionate 
• 90776-58-2 (S)-2-{(S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-propionic acid 
• 90776-58-2 (R)-2-{(S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-propionic acid 
• 85260-55-5 (2RS,3SR)-3-hydroxy-2-methyl-3-phenyl-1-(2-thioxo(1,3-thiazolidin-3-yl))propan-1-one 
• 85260-55-5 threo-3-(3-hydroxy-2-methyl-3-phenylpropanoyl)-thiazolidine-2-thione 
• 4949-44-4 ethyl propanoylacetate 
• 85260-62-4 (2S,3S)-3-(Isopropyl-dimethyl-silanyloxy)-2-methyl-3-phenyl-1-(2-thioxo-thiazolidin-3-yl)-propan-1-one 

Relevant articles and documents

Synthesis and Fungicidal Activity of Simple Structural 1,3-Thiazolidine-2-Thione Derivatives

A series of simple structural 1,3-thiazolidine-2-thione derivatives with various substituents on the S-, N-, 4-, and 5-positions was synthesized with high yields from various vicinal amino alcohols via two steps and screened for their antifungal activity. Bioassay results reveal that some thiazolidine-2-thione derivatives show strong antifungal activities against P. capsici, G. zeae, S. sclerotiorum, A. alternata, B. cinerea, or R. solani. The SAR analysis indicates that N-acyl substituted and 4-alkyl substituents can enhance the antifungal activity. Notably, 4-isopropyl-N-propionylthiazoldine-2-thione shows excellent activity against B. cinerea and G. zeae with IC50 values at 3.7 g/mL and 6.5 g/mL, respectively, and 4-isobutyl-N-propionylthiazoldine-2-thione shows remarkable fungicidal activity against R. solani, S. sclerotiorum, and G. zeae with IC50 values at 1.0 g/mL, 12.1 g/mL, and 11.0 g/mL, respectively. GRAPHICAL ABSTRACT.

On the influence of chiral auxiliaries in the stereoselective cross-coupling reactions of titanium enolates and acetals

Titanium enolates from chiral N-propanoyl-1,3-thiazolidine-2-thiones containing bulky substituents at C4 turned out to be excellent platforms to get highly stereocontrolled cross-coupling reactions with acetals. Related oxazolidinethiones also afforded go