852471-30-8

Basic information

• Product Name: 1-[(4-methylphenyl)sulfonyl]-4-phenyl-1H-pyrazole
• Synonyms: 1-[(4-methylphenyl)sulfonyl]-4-phenyl-1H-pyrazole
• CAS NO: 852471-30-8
• Molecular Weight: 298.365
• Mol File: 852471-30-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-[(4-methylphenyl)sulfonyl]-4-phenyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-methylphenyl)sulfonyl]-4-phenyl-1H-pyrazole(852471-30-8)
• EPA Substance Registry System: 1-[(4-methylphenyl)sulfonyl]-4-phenyl-1H-pyrazole(852471-30-8)

Safety Data

• Hazardous Substances Data: 852471-30-8(Hazardous Substances Data)

Upstream product

• 116228-40-1 4-iodo-1-[(4-methylphenyl)sulfonyl]-1H-pyrazole 
• 98-80-6 phenylboronic acid 
• 116228-41-2 4-bromo-1H-pyrazol-1-yl(4-methylphenyl)sulfone 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 10199-68-5 4-phenyl-1H-pyrazole 
• 10183-74-1 withasomnine 
• 457925-19-8 4-phenyl-1-[3-(phenylselanyl)propyl]-1H-pyrazole 

Relevant articles and documents

Direct synthesis of pyrazolo[5,1-a]isoindoles via intramolecular palladium-catalyzed C-H bond activation

An efficient, direct synthesis of pyrazolo-[5,1-a]isoindoles employing a palladium-catalyzed intramolecular C-H bond activation of 1-(2-halobenzyl) pyrazoles has been developed. The use of lithium chloride (LiCl) was found to be essential in these reactions, to suppress further C-H bond activation at the C-3 position of pyrazolo[5,1-a]isoindole, when C-3 is unsubstituted. This protocol can be applied to the synthesis of a pyrazolo[5,1-a]isoquinoline possessing a six-membered central ring system and a fully substituted pyrazolo[5,1-a]isoindole using sequential intra- and intermolecular C-H bond activation.

Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them

The present invention relates to the novel derivatives of formula (I) in which A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a (C3-C6) alkynyl, a (C3-C7) cycloalkyl or a (C5-C7) cycloalkenyl, R1 is an NR6R7, (C4-C7) azacycloalkyl, (C5-C7) azacycloalkenyl, (C5-C9) azabicycloalkyl or (C5-C9) azabicycloalkenyl group; A-R1 is such that the nitrogen of R1 and the nitrogen in the 1-position of the pyrazole are necessarily separated by at least two carbon atoms, R3 is an H, halogen, OH, SH, NH2, ORc, SRc, SORa, SO2Ra, NHCHO, NRaRb, NHC(O)Ra, NHC(S)Ra or NHSO2Ra, R4 is an aryl or heteroaryl; and R5 is an H, halogen, CF3, CHF2, CH2F, linear or branched (C1-C6) alkyl or (C3-C7) cycloalkyl to their racemates, enantiomers and diastereoisomers and to their mixtures, their tautomers and to their pharmaceutically acceptable salts.