852391-45-8

Basic information

• Product Name: 7-Bromo-DL-tryptophan
• Synonyms: 7-Bromotryptophan;Tryptophan, 7-bromo-;(S)-2-amino-3-(7-bromo-1H-indol-3-yl)propanoic acid;2-Amino-3-(7-bromo-1H-indol-3-yl)propanoic acid
• CAS NO: 852391-45-8
• Molecular Formula: C11H11BrN2O2
• Molecular Weight: 283.12
• Mol File: 852391-45-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 495.849 °C at 760 mmHg
• Flash Point: 253.68 °C
• Appearance: /
• Density: 1.704
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.21±0.10(Predicted)
• CAS DataBase Reference: 7-Bromo-DL-tryptophan(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-DL-tryptophan(852391-45-8)
• EPA Substance Registry System: 7-Bromo-DL-tryptophan(852391-45-8)

Safety Data

• Hazardous Substances Data: 852391-45-8(Hazardous Substances Data)

Usage

General Description

7-Bromo-DL-tryptophan is a chemical compound that belongs to the class of tryptophan derivatives. It is an amino acid derivative with a bromo substituent at the 7-position of the indole ring. 7-Bromo-DL-tryptophan has potential applications in the field of medicinal chemistry and pharmaceuticals, as it may exhibit biological activities such as antimicrobial, anticancer, and antioxidant properties. The bromo substitution on the tryptophan molecule can alter its pharmacological and physiological properties, making it a valuable compound for research and drug development. Additionally, 7-Bromo-DL-tryptophan may also be used as a precursor for the synthesis of other bioactive compounds and chemical intermediates.

Upstream product

• 75816-18-1 N-acetyl-7'-bromo-DL-tryptophan 
• 852391-42-5 2-(7-Bromo-1H-indol-3-ylmethyl)-2-formylamino-malonic acid diethyl ester 
• 852391-39-0 (7-bromo-1H-indol-3-yl)-N,N-dimethylmethanamine 
• 51417-51-7 7-bromo-1H-indole 

Downstream Products

• 75816-19-2 (S)-7-bromo-tryptophan 
• 496929-99-8 7'-bromo-D-tryptophan 
• 1219432-58-2 C₁₆H₁₉BrN₂O₄ 
• 1598418-85-9 C₂₁H₂₀BrN₃O₃ 
• 1598418-66-6 C₂₂H₂₂BrN₃O₃ 
• 1598418-65-5 C₂₂H₂₂BrN₃O₃ 
• 732983-21-0 (+/-)-7-bromotryptophan methyl ester 

Relevant articles and documents

Total synthesis of ent-(-)-azonazine using a biomimetic direct oxidative cyclization and structural reassignment of natural product

A biomimetic approach has been investigated and developed for the total synthesis of azonazine, an unusual marine natural cyclopeptide containing a rigid transannular 10-membered ring. A hypervalent iodine-mediated direct oxidative cyclization was success

Structure-activity relationship study of novel necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.