85141-94-2

Basic information

• Product Name: Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-
• Synonyms: Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-;2-[2-[2-(2-BroMoethoxy)ethoxy]ethoxy]-ethanol;Bromo-PEG4;Bromo-PEG4-alcohol;Br-PEG4-OH
• CAS NO: 85141-94-2
• Molecular Formula: C₈H₁₇BrO₄
• Molecular Weight: 257
• Mol File: 85141-94-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 321.7±27.0 °C(Predicted)
• Appearance: /
• Density: 1.350±0.06 g/cm3(Predicted)
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-(85141-94-2)
• EPA Substance Registry System: Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-(85141-94-2)

Safety Data

• Hazardous Substances Data: 85141-94-2(Hazardous Substances Data)

Usage

Description

Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-, also known as Bromo-PEG4-alcohol, is a PEGylated alcohol with a bromide group and a terminal hydroxyl group. The PEG (polyethylene glycol) linker provides hydrophilicity and solubility in aqueous media, while the bromide group acts as a good leaving group for nucleophilic substitution reactions. The hydroxyl group allows for further derivatization or replacement with other reactive functional groups.

Uses

Used in Pharmaceutical Industry:
Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]is used as a building block for the synthesis of various pharmaceutical compounds. The PEG linker enhances the solubility and stability of the resulting compounds, while the bromide group facilitates the attachment of other functional groups or molecules through nucleophilic substitution reactions.
Used in Drug Delivery Systems:
Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The PEG linker can be used to attach drugs or other functional groups to the terminal hydroxyl group, enabling targeted delivery and controlled release of the active ingredients.
Used in Bioconjugation:
Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]is used as a bioconjugation agent to attach biomolecules, such as proteins, peptides, or nucleic acids, to various surfaces or other molecules. The PEG linker provides steric stabilization and reduces non-specific interactions, while the bromide group allows for efficient coupling through nucleophilic substitution reactions.
Used in Chemical Synthesis:
Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]is used as an intermediate in the synthesis of various organic compounds. The PEG linker can be used to control the reactivity and selectivity of the reaction, while the bromide group and terminal hydroxyl group provide versatile points for further functionalization and derivatization.

Upstream product

• 112-60-7 Tetraethylene glycol 
• 75-21-8 oxirane 
• 81764-55-8 2-bromo<1,1,2,2-2H4>ethanol 
• 77544-60-6 p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester 
• 126491-78-9 12-<4'-(benzo-15-crown-5)sulfonyl>-3,6,9,12-tetraoxa-1-dodecanol 

Downstream Products

• 10108-25-5 tetraethylene glycol monooleate 
• 1417220-90-6 methyl 2-diazo-2-(4-((4-(2-(2-(2-(2-(4-(prop-2-yn-1-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)phenyl)acetate 
• 1417220-99-5 methyl 2-(4-((4-(2-(2-(2-(2-(4-(prop-2-yn-1-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)phenyl)acetate 
• 1417220-97-3 tert-butyl 4-(2-(2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethoxy)ethyl)piperazine-1-carboxylate 
• 90952-27-5 2-(2-(2-(2-mercaptoethoxy)ethoxy)ethoxy)ethan-1-ol 

Relevant articles and documents

Monothiols derived from glycols as agents for stabilizing gold colloids in water: Synthesis, self-assembly and use as crystallization templates

Tetraethylene glycol (HO-(C2H4O)4-H) can be monofunctionalized by replacing one of the terminal hydroxy groups with the thiol SH group. The resulting molecule can be self-assembled on gold (111) surfaces. More importantly, this molecule allows the simple one-step preparation of protected, water-soluble gold colloids within a single aqueous phase. Attempts are made to use such protected water-soluble colloids as nucleating 'seeds' around which calcium carbonate can be crystallized.

Complex compound

PROBLEM TO BE SOLVED: To provide a new complex compound that can be used as a catalyst for an organic synthesis reaction and in particular a surfactant type catalyst having both functions of catalytic ability and surface active ability. SOLUTION: A complex compound comprises a nitrogen-containing heterocyclic carbene ligand represented by formula (A) and including at least one metal atom selected from palladium, silver, rhodium, iridium, and ruthenium as a central metal. (R1 represents a divalent hydrocarbon group that has 2-20 carbon atoms and may include at least one atom selected from N, O, S and halogen atoms; R2 represents a hydrocarbon group having 6-70 carbon atoms and including a polyoxyalkylene group and/or a polyglyceryl group having a polymerization number of 2-20 or a hydrocarbon group having 2-20 carbon atoms and including at least one ionic functional group selected from a sulfonic acid group, a carboxyl group, an ammonium group, or their salts; and R3 represents a hydrocarbon group having 2-20 carbon atoms) SELECTED DRAWING: None COPYRIGHT: (C)2016,JPO&INPIT

Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems

A range of monocationic and dicationic dioxyalkylglycerol cytofectins have been synthesised possessing methylene and short n-ethylene glycol spacers. The monocationic compounds were found to be effective in transfections when formulated as lipopolyplexes with peptide and DNA components, in particular with shorter PEG head groups which may have less effect on peptide targeting in the ternary complex. The Royal Society of Chemistry 2008.