85068-27-5 Usage
Description
2,5-Difluorophenylacetic acid is an organic compound characterized by the presence of two fluorine atoms at the 2nd and 5th positions on a phenyl ring, attached to an acetic acid group. This unique structure endows it with specific chemical properties that make it a valuable intermediate in the synthesis of various organic compounds.
Uses
Used in Pharmaceutical Industry:
2,5-Difluorophenylacetic acid is used as a key intermediate in the synthesis of pharmaceutical compounds for its ability to impart specific biological activities to the final product. Its unique structure allows for the development of new drugs with improved efficacy and selectivity.
Used in Organic Synthesis:
2,5-Difluorophenylacetic acid is used as a building block in the synthesis of various organic compounds, including agrochemicals, dyes, and other specialty chemicals. Its reactivity and structural features make it a versatile component in the creation of complex molecules with specific properties.
Specific Application:
2,5-Difluorophenylacetic acid is used in the synthesis of 2,2-dimethyl-4-(2,5-difluorophenyl)-5-[4-(aminosulfonyl)phenyl]-3(2H)-furanone, a compound with potential applications in various fields, such as pharmaceuticals or materials science. Its role in this synthesis highlights its utility as a starting material for creating complex and functionalized molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 85068-27-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,0,6 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 85068-27:
(7*8)+(6*5)+(5*0)+(4*6)+(3*8)+(2*2)+(1*7)=145
145 % 10 = 5
So 85068-27-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H6F2O2/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3H,4H2,(H,11,12)
85068-27-5Relevant articles and documents
Electrochemical direct carboxylation of benzyl alcohols having an electron-withdrawing group on the phenyl ring: One-step formation of phenylacetic acids from benzyl alcohols under mild conditions
Senboku, Hisanori,Yoneda, Kenji,Hara, Shoji
, p. 6772 - 6776 (2016/01/30)
Electrochemical direct carboxylation of benzyl alcohols having an electron-withdrawing group on the phenyl ring was successfully carried out by constant current electrolysis using an undivided cell equipped with a platinum plate cathode and a magnesium rod anode in DMF in the presence of carbon dioxide. Reductive cleavage of the C-O bond followed by fixation of carbon dioxide efficiently took place at the benzylic position without any additive to give the corresponding phenylacetic acids in good yields in one step under neutral and mild conditions.
Synthesis of dihalophenylacetic acids using aromatic nucleophilic substitution strategy
Kowalczyk, Bruce A.
, p. 1411 - 1414 (2007/10/03)
A simple synthetic strategy to dihalophenylacetic acids and specifically 3,5-difluorophenylacetic acid an important pharmaceutical intermediate was developed. The aromatic nucleophilic substitution of dihalofluorobenzenes using the anion of ethyl cyanoacetate yielded ethyl dihalophenylcyanoacetates. The basic decarboxylation of the ethyl dihalophenylcyanoacetates produced targeted dihalophenylacetic acids.
