84633-27-2Relevant articles and documents
Biomimetic Synthesis Enables the Structure Revision of Littordials e and F and Drychampone B
Vieira De Castro, Tomás,Yahiaoui, Oussama,Peralta, Ricardo A.,Fallon, Thomas,Lee, Victor,George, Jonathan H.
, p. 8161 - 8166 (2020)
Structural reassignments for littordial E, littordial F, and drychampone B are proposed on the basis of consideration of their biosynthetic origin. The key step in the proposed biosynthesis of each of these meroterpenoids is an intermolecular hetero-Diels-Alder reaction between an o-quinone methide and caryophyllene or humulene. Biomimetic total synthesis of the natural products gave sufficient material to allow their structure revision by NMR studies.