84485-00-7

Basic information

• Product Name: Sibutramine hydrochloride
• Synonyms: SIBUTRAMINE HCL;SIBUTRAMINE HYDROCHLORIDE;REDUCTIL;BTS 54524;MERIDIA;1-(4-CHLOROPHENYL)-N,N-DIMETHYL-BETA-(2-METHYLPROPYL)CYCLOBUTANEMETHANAMINE HYDROCHLORIDE;SIBUTRAMINE HCL ENTERPRISE STANDARD HPLC 99%;SIBUTRAMINE HCL MONOHYDRATE 99.6+%
• CAS NO: 84485-00-7
• Molecular Formula: C17H27Cl2N
• Molecular Weight: 316.31
• Product Categories: APIs;Weight Loss;Pharmaceutical intermediate
• Mol File: 84485-00-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 190-200°C
• Boiling Point: 348.119 °C at 760 mmHg
• Flash Point: 164.337 °C
• Appearance: /
• Density: 1.026 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.527
• Storage Temp.: Store at RT
• CAS DataBase Reference: Sibutramine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Sibutramine hydrochloride(84485-00-7)
• EPA Substance Registry System: Sibutramine hydrochloride(84485-00-7)

Safety Data

• Hazardous Substances Data: 84485-00-7(Hazardous Substances Data)

Usage

Description

Sibutramine hydrochloride is a pharmaceutical compound that functions as a 5-HT and noradrenaline reuptake inhibitor. It is primarily recognized for its antidepressant properties and has been utilized in the development of medications aimed at treating obesity by suppressing appetite.
Used in Pharmaceutical Industry:
Sibutramine hydrochloride is used as an antidepressant for its ability to modulate neurotransmitter levels, specifically by inhibiting the reuptake of serotonin (5-HT) and noradrenaline. This action contributes to an enhancement in mood and emotional well-being, making it a valuable component in the treatment of depression and related disorders.
Additionally, Sibutramine hydrochloride is used as an appetite suppressant in the weight loss management industry. By inhibiting the reuptake of certain neurotransmitters, it helps to reduce hunger and increase satiety, which can assist individuals in maintaining a calorie deficit and achieving their weight loss goals.
Used in Dietary Supplements Screening:
Sibutramine hydrochloride monohydrate has been utilized as a standard for screening dietary supplements for the presence of sibutramine using ion mobility spectrometer. This application is crucial for ensuring the safety and quality of dietary supplements, as it helps to detect and prevent the illegal addition of sibutramine to these products, which can have potentially harmful effects on consumers.

Weight loss pills

Sibutramine hydrochloride is a weight loss drug, it is hydrochloride salt form of sibutramine , and the pharmacological effects are fully consistent with of sibutramine , but the stability and solubility are better than sibutramine. Sibutramine hydrochloride is firstly used to treat depression, in their clinical application process , people find that the effect of weight loss is significantly stronger than the effect of the antidepressant . On one hand ,by inhibiting the reuptake of serotonin, which makes the body reduce hunger, it can suppress appetite and control caloric intake effectively ; on the other hand, by activating the adrenergic receptors, which increases adipose tissue consumption, it can increase metabolism and energy consumption;it has obvious weight loss effect, but it may cause endangering serious side effects such as high blood pressure, high heart rate, anorexia, insomnia, abnormal liver function. The above information is edited by the lookchem of Tian Ye.

Precautions

Sibutramine hydrochloride belongs to the serotonin and norepinephrine reuptake inhibitors, it has the dual role of inhibiting appetite and enhancing metabolism, it can be used for the treatment of obesity which diet and exercise can not control. There are many taboos in clinical practice of sibutramine hydrochloride , for example, patients with severe hypertension or patients with severe liver and kidney dysfunction, or patients with angle-closure glaucoma and women after childbirth, should not use it . Because the physiological effects of 16 years old or younger minors have not yet been confirmed, use of it should be prohibited. Also doses should be strictly controlled by users, the recommended starting dose is 10 mg per day for adults, the maximum should not exceed 15 mg. If there is overdose, patients should go to hospital for treatment, there is no specific antidote, only symptomatic treatment can be taken in clinic.

Biological Activity

5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.

Biochem/physiol Actions

Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.

InChI:InChI=1/C17H26ClN/c1-12(2)11-17(19(3)4)16-10-9-15(16)13-5-7-14(18)8-6-13/h5-8,12,15-17H,9-11H2,1-4H3