84082-64-4

Basic information

• Product Name: Gastric Mucin
• Synonyms: MUCIN;MUCIN GASTRIC;MUCIN, GASTRIC, HOG;MUCIN TYPE I;MUCIN TYPE II;MUCIN TYPE III;MUCIN TYPE I-S;GASTRIC MUCIN PORCINE
• CAS NO: 84082-64-4
• Molecular Formula: NULL
• Molecular Weight: 0
• EINECS: 282-357-4
• Product Categories: Mucin;Proteins and Derivatives;Structural Proteins
• Mol File: 84082-64-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /partially purified powder
• Storage Temp.: 2-8°C
• Solubility: 1 M NaOH: soluble20mg/mL
• CAS DataBase Reference: Gastric Mucin(CAS DataBase Reference)
• NIST Chemistry Reference: Gastric Mucin(84082-64-4)
• EPA Substance Registry System: Gastric Mucin(84082-64-4)

Safety Data

• Safety Statements: S22:; S24/25:
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 84082-64-4(Hazardous Substances Data)

Usage

Description

Gastric Mucin, also known as mucus glycoproteins, are high-molecular-weight glycoproteins expressed throughout the gastrointestinal tract, particularly in the stomach. They play a key role in mucosal protection and function, providing a protective barrier against harmful substances and pathogens. Gastric Mucin is composed of various subtypes, including MUC5AC, MUC1, and MUC2, which have distinct roles in the gastrointestinal system.

Uses

Used in Pharmaceutical Industry:
Gastric Mucin is used as a pharmaceutical ingredient for its mucosal protective properties. It helps to maintain the integrity of the gastrointestinal lining and prevents damage caused by acidic gastric juices, enzymes, and other harmful substances.
Used in Research Applications:
Gastric Mucin is used as a research tool for studying the binding sites of various proteins and enzymes, such as the galactose-specific agglutinin PA-IL from Pseudomonas aeruginosa. This helps in understanding the interactions between Gastric Mucin and other molecules, which can be useful in developing new therapeutic agents and diagnostic tools.
Used in Diagnostic Applications:
Gastric Mucin is used in diagnostic applications for the detection of acid-fast bacilli in sputum smears concentrated by cyto-centrifugation. This aids in the diagnosis of gastrointestinal infections and other related conditions.
Used in Cancer Research:
Gastric Mucin is used in cancer research to study the changes in the expression of MUC5AC, MUC1, and MUC2 in gastric cancer. Understanding these changes can help in the development of targeted therapies and early detection methods for gastric cancer.

Biological Activity

Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin-17 (MUC17) was more highly expressed in gastric cancer (GC) specimens, with favourable prognosis for patients.

Biochem/physiol Actions

Mucus forms the protective cover for all epithelial surfaces. The major structural component of mucus is gel-forming mucins. The mucus layer covering the intestinal epithelium has the MUC2 mucin as its central molecule. MUC2 is produced by goblet cells.

InChI:InChI=1/C97H124N20O31S/c1-49(2)39-68(114-95(146)71(43-54-46-100-59-18-11-9-16-57(54)59)116-97(148)73-19-12-37-117(73)76(121)48-102-85(136)60-24-30-74(119)104-60)93(144)110-65(29-35-81(130)131)91(142)109-64(28-34-80(128)129)90(141)108-63(27-33-79(126)127)89(140)107-62(26-32-78(124)125)88(139)106-61(25-31-77(122)123)87(138)103-50(3)84(135)113-69(41-52-20-22-55(118)23-21-52)86(137)101-47-75(120)105-70(42-53-45-99-58-17-10-8-15-56(53)58)94(145)111-66(36-38-149-4)92(143)115-72(44-82(132)133)96(147)112-67(83(98)134)40-51-13-6-5-7-14-51/h5-11,13-18,20-23,45-46,49-50,60-73,99-100,118H,12,19,24-44,47-48H2,1-4H3,(H2,98,134)(H,101,137)(H,102,136)(H,103,138)(H,104,119)(H,105,120)(H,106,139)(H,107,140)(H,108,141)(H,109,142)(H,110,144)(H,111,145)(H,112,147)(H,113,135)(H,114,146)(H,115,143)(H,116,148)(H,122,123)(H,124,125)(H,126,127)(H,128,129)(H,130,131)(H,132,133)