83915-83-7 Usage
Description
Lisinopril, also known as 1-[N2-[S-1-carboxy-3-phenylpropyl]-L-lysyl]-L-proline dihydrate (Prinivil, Zestril), is a lysine derivative of enalaprilat, the active metabolite of enalapril. It is an orally active angiotensin-converting enzyme (ACE) inhibitor and is structurally related to enalaprilat. Lisinopril is a white to off-white crystalline powder that is useful in the management of hypertension and congestive heart failure. As an ACE inhibitor, it acts as an active site-directed inhibitor of the enzyme, with the zinc ion used in an effective binding interaction at a stoichiometric ratio of 1:1. The pharmacological effects of lisinopril are similar to those of captopril and enalapril.
Uses
Used in Pharmaceutical Industry:
Lisinopril is used as an ACE inhibitor for the management of hypertension and congestive heart failure. It helps in lowering blood pressure and improving heart function by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor.
Used in Analytical Applications:
Lisinopril is used as a Secondary Standard in several analytical applications, including but not limited to pharmaceutical release testing, pharmaceutical method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. These Secondary Standards are qualified as Certified Reference Materials, ensuring accurate and reliable results in various testing and analysis processes.
Biochem/physiol Actions
Angiotensin converting enzyme (ACE) inhibitor.
Clinical Use
Many new ACE inhibitors became available for the treatmentof hypertension following the clinical effectivenessof enalapril. Enalapril is a non–thiol-containing ACE inhibitordevoid of the side effects of rash and loss of thesense of taste characteristic of the thiol-containing compoundcaptopril. With the exception of the phosphoruscontainingfosinopril, these antihypertensive agents havea 2-, like the prototypical drug captopril,are used in the treatment of mild-to-moderate hypertension,either alone or in conjunction with diuretics orcalcium channel blockers.
Veterinary Drugs and Treatments
The principle uses of lisinopril in veterinary medicine at present are
as a vasodilator
in the treatment of heart failure or hypertension.
Recent studies have demonstrated that ACE inhibitors, particularly
when used in conjunction with furosemide, do improve the quality
of life in dogs with heart failure. It is not clear, however, whether it
has any significant effect
on survival times. Lisinopril may also be of
benefit in treating the effects associated with valvular heart disease
(mitral regurgitation) and left to right shunts. It is being explored
as adjunctive treatment in chronic renal failure and in protein losing
nephropathies.
Lisinopril may have advantages over other ACE inhibitors in
that it may be dosed once daily and less expensive. Disadvantages
are that it is only available in human labeled dosage forms and there
is much less published information on its use (efficacy, safety, dosing)
in veterinary species.
Check Digit Verification of cas no
The CAS Registry Mumber 83915-83-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,9,1 and 5 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 83915-83:
(7*8)+(6*3)+(5*9)+(4*1)+(3*5)+(2*8)+(1*3)=157
157 % 10 = 7
So 83915-83-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17?,18-;;/m0../s1