83852-56-6 Usage
Description
Chrysomycin B is an antibiotic isolated from a strain of Streptomyces. It differs from its analog chrysomycin A by having a methyl, rather than vinyl, group in the 8-position of the chromophore. Like its analog, chrysomycin B suppresses the growth of transplantable tumors in mice, an effect that may be related to its ability to bind DNA. It also causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II. Chrysomycin B is structurally very similar to gilvocarcin V, which promotes DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light.
Uses
Used in Anticancer Applications:
Chrysomycin B is used as an antitumor agent for its ability to suppress the growth of transplantable tumors in mice. It is a potent inhibitor of the catalytic activity of human topoisomerase II and may act as a photoactivated cross-linker of DNA to histones, contributing to its anticancer properties.
Used in Pharmaceutical Industry:
Chrysomycin B is used as a research compound for studying the mechanisms of action of antibiotics and their potential applications in cancer treatment. Its structural similarity to gilvocarcin V allows for investigations into DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light, which could lead to the development of novel therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 83852-56-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,8,5 and 2 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 83852-56:
(7*8)+(6*3)+(5*8)+(4*5)+(3*2)+(2*5)+(1*6)=156
156 % 10 = 6
So 83852-56-6 is a valid CAS Registry Number.
InChI:InChI=1/C27H28O9/c1-11-8-15-19(17(9-11)33-4)14-10-18(34-5)21-16(28)7-6-13(20(21)22(14)36-26(15)31)23-25(30)27(3,32)24(29)12(2)35-23/h6-10,12,23-25,28-30,32H,1-5H3/t12-,23+,24+,25+,27-/m1/s1
