835-31-4 Usage
Description
Naphazoline is a potent sympathomimetic drug that acts as a vasoconstrictor, primarily used in the treatment of nasal congestion and related conditions.
Uses
Used in Pharmaceutical Industry:
Naphazoline is used as a nasal decongestant for the relief of severe rhinitis associated with colds, allergic reactions, and chronic inflammatory conditions. It helps to reduce nasal congestion by constricting the blood vessels in the nasal mucosa, thereby decreasing swelling and improving airflow.
Used in Medical Treatment:
Naphazoline is used for the treatment of inflammation of the antrum of Highmore, a condition characterized by swelling and inflammation in the maxillary sinus. Its vasoconstrictive properties help to alleviate symptoms and promote healing.
Additionally, Naphazoline is used for stopping nosebleeds. Its vasoconstrictive action helps to reduce blood flow to the nasal mucosa, allowing the blood vessels to constrict and stop bleeding.
Originator
Privine,Ciba,US,1942
Manufacturing Process
2.7 parts of naphthyl-(1)-acetiminoethylether hydrochloride of the formula
(produced from naphthyl-(1)-acetonitrile and methanol) are dissolved in 12
parts of absolute alcohol. 1 part of ethylenediamine is then added and the whole is heated to gentle boiling while passing nitrogen through it and
simultaneously stirring until ammonia escapes no longer. The alcohol is then
distilled and the residue mixed with 40 parts of benzene and 1.8 parts of
caustic potash. Stirring is continued for some time whereby the imidazoline
base is dissolved in benzene. The benzene residue is recrystallized several
times from toluene.
Synthesis
Naphazoline, 2-(1-naphthylmethyl)-2-imidazoline (11.1.36), is synthesized
from (1-naphthyl)acetonitrile, which upon reaction with ethanol transforms into iminoester (11.1.35), and undergoes further heterocyclization into the desired imidozoline
derivative (11.1.36) upon reaction with ethylendiamine [40].
Check Digit Verification of cas no
The CAS Registry Mumber 835-31-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,3 and 5 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 835-31:
(5*8)+(4*3)+(3*5)+(2*3)+(1*1)=74
74 % 10 = 4
So 835-31-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
835-31-4Relevant articles and documents
Preparation method of naphazoline hydrochloride
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Paragraph 0015; 0018-0019, (2021/01/24)
The invention relates to the technical field of organic synthesis, in particular to a preparation method of naphazoline hydrochloride, which comprises the following steps: by using alpha-naphthylacetic acid, ethylenediamine and acetone as raw materials, carrying out condensation, cyclization, salification and the like to prepare 4, 5-dihydro-2-(1-naphthyl methyl)-1H-imidazole hydrochloride. Alpha-naphthylacetic acid, ethylenediamine and acetone are used as raw materials to prepare the target product, and the raw materials are easy to obtain and low in price. Condensation, cyclization and salification are adopted, the operation reaction conditions are mild, a large number of side reactions are avoided, and the high yield is obtained. The preparation process is high in coherence, short in time consumption and more efficient and thorough in reaction. The preparation process is simple, reaction conditions are mild, and environmental pollution is avoided.
Colloid and nanosized catalysts in organic synthesis: XIII. Synthesis of 2-R-2-imidazolines catalyzed by copper and iron oxide nanoparticles
Popov,Mokhov,Kalitina
, p. 281 - 285 (2016/04/20)
The reaction of carboxylic acids with ethylenediamine catalyzed by copper or iron oxide nanoparticles proceeds at 80°C with azeotropic water distilling off during 2-8 h to form 2-R-2-imidazolines. Acyl and diacyl derivatives of ethylenediamine are formed in the reaction as side products.
Feed additive for improving growth in agricultural animals
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, (2008/06/13)
By using α-mimetics, particularly compounds of general formulae I to III and the compounds listed in Table I, as feed additives in fattening animals, it has surprisingly been possible to improve the daily weight gain, the utilisation of fodder and the ratio of muscle to fat in favor of the proportion of muscle and protein.