82382-23-8 Usage
Description
Sulconazole Nitrate is an imidazole antifungal agent closely related to econazole, known for its effectiveness in treating a broad spectrum of superficial fungal infections.
Uses
Used in Pharmaceutical Industry:
Sulconazole Nitrate is used as an antifungal agent for the topical treatment of various superficial fungal infections. It is effective against a wide range of fungi, making it a versatile choice for treating different types of fungal infections.
Used in Dermatological Applications:
In dermatology, Sulconazole Nitrate is used as a topical medication for treating skin infections caused by fungi. Its antifungal properties help in reducing inflammation, itching, and other symptoms associated with fungal skin infections.
Brand Name:
Sulconazole Nitrate is marketed under the brand name Exelderm by Westwood-Squibb. This brand is specifically formulated for dermatological use, providing an effective solution for treating fungal skin infections.
Biological Activity
Sulconazole Nitrate is an imidazole derivative with broad-spectrum antifungal activity.
Clinical Use
1-[2,4-Dichloro-β-[p-chlorobenzyl)thio]phenethyl]imidazolemononitrate (Exelderm) is the white crystalline nitricacid salt of sulconazole. It is sparingly soluble in water butsoluble in ethanol. The salt is used in a solution and a cream in 1% concentration for the treatment of local tinea infections,such as jock itch, athlete’s foot, and ringworm.
in vitro
Sulconazole Nitrate possesses a broad spectrum of activity in vitro against dermatophytes, yeasts and some Gram-positive bacteria at concentrations below 5 mg/L in vitro. It has been shown that against representatives of pathogenic yeasts, dermatophytes and Aspergilli, the RIF values of sulconazole are broadly similar to those of other imidazoles. The fungicidal potency of sulconazole in vitro depends on its concentration and on the growth phase of the inoculum cells. Sulconazole has also demonstrated antibacterial activity in vitro, with MIC values below 12.5 mg/L.
in vivo
The efficacy and safety of sulconazole 1% cream has been demonstrated in controlled clinical studies in patients with superficial dermatophyte or yeast infections. To minimise the risk of reinfection treatment should continue for 3 weeks in Candida infections, tinea cruris, tinea corporis and pityriasis versicolor, and for 4 weeks in patients with tinea pedis.
Check Digit Verification of cas no
The CAS Registry Mumber 82382-23-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,3,8 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 82382-23:
(7*8)+(6*2)+(5*3)+(4*8)+(3*2)+(2*2)+(1*3)=128
128 % 10 = 8
So 82382-23-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H15Cl3N2S.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
82382-23-8Relevant articles and documents
Methods and compositions for intravaginal contraception
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, (2008/06/13)
A gel formulation, which is inherently spermicidal and which provides an efficient delivery system for spermicidal and other contraceptively effective compounds intravaginally is disclosed. Said formulation is useful in methods of intravaginal contraception.
