82359-63-5Relevant articles and documents
Probes for Narcotic Receptor Mediated Phenomena. 9. Synthesis of (+/-)-(3α,6aα,11aβ)-1,3,4,5,6,11a-Hexahydro-2-methyl-2H-3,6a-methanobenzofuroazocin-10-ol, an Oxide-Bridged 5-(m-Hydroxyphenyl)morphan
Burke, Terrence R.,Jacobson, Arthur E.,Rice, Kenner C.,Weissman, Ben Avi,Huang, Hsueh-Cheng,Silverton, J. V.
, p. 748 - 751 (2007/10/02)
The synthesis of racemic (3α,6aα,11aβ)-1,3,4,5,6,11a-hexahydro-2-methyl-2H-3,6a-methanobenzofuroazocin-10-ol (2d) is described.The route used acid-catalyzed ring closure of enamine 5 to yield the unsaturated phenylmorphan 6.Conversion of 6 to oxide
Convenient Synthesis of 3-Methyl-2,3,4,4aα,5,6,7,7aα-octahydro-1H-benzofuroisoquinoline
Shenvi, Ashok B.,Ciganek, Engelbert
, p. 2942 - 2947 (2007/10/02)
A new synthesis of 3-methyl-2,3,4,4aα,5,6,7,7aα-octahydro-1H-benzofuroisoquinoline (3) has been developed.The synthesis utilizes the acylation of anion 5 with γ-butyrolactone preferentially at the 4-position.Reduction of the resulting keto alcohol
STUDIES DIRECTED TOWARDS THE TOTAL SYNTHESIS OF MORPHINE ALKALOIDS
Evans, D. A.,Mitch, C. H.
, p. 285 - 288 (2007/10/02)
Application of metallated enamines to the synthesis of morphine related congeners is reported.A formal total synthesis of (+/-)-morphine has been completed.