82005-12-7 Usage
Description
10Z-HYMENIALDISINE is a marine sponge alkaloid, a natural product that possesses potent inhibitory activity against a variety of kinases, including MEK-1, GSK-3, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at micromolar concentrations.
Uses
Used in Pharmaceutical Industry:
10Z-HYMENIALDISINE is used as a kinase inhibitor for its ability to target and inhibit the activity of MEK-1, GSK-3, and CKI kinases. This makes it a potential candidate for the development of drugs to treat various diseases, including cancer, by modulating cellular signaling pathways.
Used in Cancer Research:
10Z-HYMENIALDISINE is used as a research tool for studying the role of MEK-1, GSK-3, and CKI kinases in cancer cell growth and proliferation. Its ability to inhibit the G2 cell cycle checkpoint at micromolar concentrations makes it a valuable compound for investigating the mechanisms of cell cycle regulation and the development of targeted cancer therapies.
Used in Drug Discovery:
10Z-HYMENIALDISINE is used as a lead compound in drug discovery efforts, as its potent inhibitory activity against various kinases suggests that it may serve as a starting point for the development of new drugs with improved efficacy and selectivity. Structure-activity relationship studies can be conducted to optimize its properties and identify more effective and targeted therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 82005-12-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,0,0 and 5 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 82005-12:
(7*8)+(6*2)+(5*0)+(4*0)+(3*5)+(2*1)+(1*2)=87
87 % 10 = 7
So 82005-12-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H10BrN5O2/c12-6-3-5-4(7-10(19)17-11(13)16-7)1-2-14-9(18)8(5)15-6/h3,15H,1-2H2,(H,14,18)(H3,13,16,17,19)/b7-4+
82005-12-7Relevant articles and documents
A new glycociamidine ring precursor: Syntheses of (Z)-hymenialdisine, (Z)-2-debromohymenialdisine, and (±)-endo-2-debromohymenialdisine
Papeo, Gianluca,Posteri, Helena,Borghi, Daniela,Varasi, Mario
, p. 5641 - 5644 (2007/10/03)
(Chemical Equation Presented) The synthesis of the C11H 5 marine sponge alkaloids, (Z)-hymenialdisine and (Z)-2-debromohymenialdisine, is described. A key step was the condensation between aldisine or its monobromo derivative and a n
Synthetic method of hymenialdisine and its derivatives and their synthetic intermediates, and those synthetic intermediates
-
, (2008/06/13)
The present invention provides hymenialdisine or its derivatives having the formula (I): STR1 wherein X 1 is a halogen atom or a hydrogen atom and a process for production of the same. Further, synthetic intermediates are included in the invention. Hymenialdisine and its derivatives have inhibitory effects against protein kinase C and can be expected to have applications as a drug for the treatment of conditions where it is believed the activation of protein kinase C is involved.
Total Syntheses of Hymenialdisine and Debromohymenialdisine: Stereospecific Construction of the 2-Amino-4-Oxo-2-Imidazolin-5(Z)-Disubstituted Ylidene Ring System
Annoura, Hirokazu,Tatsuoka, Toshio
, p. 413 - 416 (2007/10/02)
The first total synthesis of hymenialdisine (1a) and debromohymenialdisine (1b) was achieved via a novel stereospecific construction of the 2-amino-4-oxo-2-imidazoline-5(Z)-disubstituted ylidine ring system.