81123-06-0

Basic information

• Product Name: PYR-ARG-PRO-PRO-MET-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2
• Synonyms: GASTRIN (RAT);GASTRIN, RAT (1-17);GASTRIN (1-17), RAT;GASTRIN I (RAT);GASTRIN-1, RAT;GASTRIN I;PYR-ARG-PRO-PRO-MET-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2;PYR-RPPMEEEEEAYGWMDF-NH2
• CAS NO: 81123-06-0
• Molecular Formula: C94H128N22O31S2
• Molecular Weight: 2126.28
• Product Categories: Peptide;GastrinsIslet Stem Cell Biology;Growth Factors;Islet Stem Cell Differentiation;Neuropeptides;Peptides for Cell Biology
• Mol File: 81123-06-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: PYR-ARG-PRO-PRO-MET-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: PYR-ARG-PRO-PRO-MET-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2(81123-06-0)
• EPA Substance Registry System: PYR-ARG-PRO-PRO-MET-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2(81123-06-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 81123-06-0(Hazardous Substances Data)

Usage

Description

PYR-ARG-PRO-PRO-MET-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2, also known as Gastrin I (rat), is a small biologically active peptide that is synthesized as a precursor. It is a pyloric antral hormone produced in antral G cells and has been used in various studies for gastrin stimulation in rats.

Uses

Used in Medical Research:
PYR-ARG-PRO-PRO-MET-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2 is used as a research tool for studying the expression of histidine decarboxylase and histamine metabolism in gastric oxyntic mucosa during conditions of hypergastrinemia and carcinoid tumor in rats.
Used in Immunohistochemical Assays:
PYR-ARG-PRO-PRO-MET-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2 is used for preabsorption of anti-gastrin antibody prior to immunohistochemical assay in rats, aiding in the detection and analysis of gastrin-related processes.

Biochem/physiol Actions

Gastrin plays a crucial role in the maintenance of architecture and function of oxyntic mucosa of stomach, which is involved in the secretion of acid. It also triggers the secretion of acid into the gastric lumen. Continuous increased plasma levels of gastrin or hypergastrinemia, may be involved in gastrointestinal carcinogenesis, especially if it is accompanied with inflammation. The release of this peptide is suppressed during distention, which is a result of omatostatin and intrinsic cholinergic pathways. In rats, this peptide maintains gastric mucosal integrity through the up-regulation of cyclooxygenase-2 which is, in part, mediated by heparin-binding epidermal growth factor-like growth factor (HB-EGF).