80909-96-2

Basic information

• Product Name: TERT-BUTYL N-[3-(TOSYLOXY)PROPYL]CARBAMATE
• Synonyms: TERT-BUTYL N-[3-(TOSYLOXY)PROPYL]CARBAMATE;3-[(tert-Butoxycarbonyl)amino]propyl 4-methylbenzenesulfonate
• CAS NO: 80909-96-2
• Molecular Formula: C₁₅H₂₃NO₅S
• Molecular Weight: 329.41
• Mol File: 80909-96-2.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TERT-BUTYL N-[3-(TOSYLOXY)PROPYL]CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL N-[3-(TOSYLOXY)PROPYL]CARBAMATE(80909-96-2)
• EPA Substance Registry System: TERT-BUTYL N-[3-(TOSYLOXY)PROPYL]CARBAMATE(80909-96-2)

Safety Data

• Hazardous Substances Data: 80909-96-2(Hazardous Substances Data)

Upstream product

• 34619-03-9 tert-butyldicarbonate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 58885-58-8 N-tert-butoxycarbonyl-3-aminopropanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 156-87-6 propan-1-ol-3-amine 
• 41840-28-2 S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine 

Downstream Products

• 129392-84-3 tert-butyl N-(3-azidopropyl)carbamate 
• 1426687-03-7 tert-butyl (3-(((4S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl)oxy)propyl)carbamate 
• 1085928-20-6 tert-butyl (3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)carbamate 
• 913642-21-4 1,1-dimethylethyl [3-({3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methyl-1-butyn-1-yl)-1H-imidazo[4,5-c]pyridin-6-yl]phenyl}oxy)propyl]carbamate 
• 955359-92-9 1,1-dimethylethyl (3-{4-[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]hexahydro-1H-azepin-1-yl}propyl)carbamate 

Relevant articles and documents

COMPOUNDS AND USES THEREOF

The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

Azido-Desferrioxamine Siderophores as Functional Click-Chemistry Probes Generated in Culture upon Adding a Diazo-Transfer Reagent

This work aimed to undertake the in situ conversion of the terminal amine groups of bacterial desferrioxamine (DFO) siderophores, including desferrioxamine B (DFOB), to azide groups to enable downstream click chemistry. Initial studies trialed a precursor-directed biosynthesis (PDB) approach. Supplementing Streptomyces pilosus culture with blunt-end azido/amine non-native substrates designed to replace 1,5-diaminopentane as the native diamine substrate in the terminal amine position of DFOB did not produce azido-DFOB. Addition of the diazo-transfer reagent imidazole-1-sulfonyl azide hydrogen sulfate to spent S. pilosus medium that had been cultured in the presence of 1,4-diaminobutane, as a viable native substrate to expand the suite of native DFO-type siderophores, successfully generated the cognate suite of azido-DFO analogues. CuI-mediated or strain-promoted CuI-free click chemistry reactions between this minimally processed mixture and the appropriate alkyne-bearing biotin reagents produced the cognate suite of 1,4-disubstituted triazole-linked DFO-biotin compounds as potential molecular probes, detected as FeIII-loaded species. The amine-to-azide transformation of amine-bearing natural products in complex mixtures by the direct addition of a diazo-transfer reagent to deliver functional click chemistry reagents adds to the toolbox for chemical proteomics, chemical biology, and drug discovery.

For the treatment of tumor macrocyclic derivatives (by machine translation)

The invention discloses a method for modulating protein kinase activity, and is used for the treatment or prevention of protein kinase related disorders. Specifically, the invention relates to a method for the treatment of tumor of the macrocyclic derivatives, which belongs to the regulating Anaplastic lymphoma kinase (ALK) active compound, and provides the preparation method of the compound, and the compound used for the treatment or prevention of diseases associated with the ALK pharmaceutical use. (by machine translation)