8015-98-3

Basic information

• Product Name: CLOVE STEM OIL
• Synonyms: CLOVE STEM OIL
• CAS NO: 8015-98-3
• Molecular Weight: 0
• Mol File: 8015-98-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: CLOVE STEM OIL(CAS DataBase Reference)
• NIST Chemistry Reference: CLOVE STEM OIL(8015-98-3)
• EPA Substance Registry System: CLOVE STEM OIL(8015-98-3)

Safety Data

• Hazardous Substances Data: 8015-98-3(Hazardous Substances Data)

Usage

Description

CLOVE STEM OIL is a pale-yellow to straw-yellow liquid derived from the stems of the tree Eugenia caryophyllata Thunb. (Fam. Myrtaceae). It is soluble in fixed oils and propylene glycol, but relatively insoluble in glycerin and mineral oil. The oil is obtained by steam distillation of the dried flower stems and has a sweet-spicy, slightly woody odor similar to that of bud oil but without the fresh, fruity top note.

Uses

Used in Flavor and Fragrance Industry:
CLOVE STEM OIL is used as a flavoring agent for its sweet-spicy, slightly woody odor. It is commonly used in the formulation of various food and beverage products, as well as in the production of perfumes and other fragrances.
Used in Pharmaceutical Industry:
CLOVE STEM OIL is used as an active ingredient in various pharmaceutical products due to its phenol content, which ranges from 85-95% (v/v). The oil's main components include eugenol (83-92%), caryophyllene (4-12%), and eugenol acetate (0.5-4%). These compounds possess antimicrobial, anti-inflammatory, and analgesic properties, making the oil useful in the development of medications for various health conditions.
Used in Cosmetic Industry:
CLOVE STEM OIL is used as a natural ingredient in cosmetic products, such as creams, lotions, and soaps, due to its pleasant odor and potential skin care benefits. The oil's antimicrobial and anti-inflammatory properties can contribute to the development of products that promote skin health and well-being.
Used in Aromatherapy:
CLOVE STEM OIL is used in aromatherapy for its potential therapeutic effects. The oil's sweet-spicy, slightly woody aroma can help create a relaxing and soothing atmosphere, promoting mental and emotional well-being.

Preparation

By steam distillation of the dried stems of E. caryophyllata Thunb. after removal of the buds.

Essential oil composition

Similar to the leaf oil, clove stem oil has a high composition of eugenol, making it a preferred source for eugenol and subsequent conversion to isoeugenol, derivatives of eugenol and vanillin. Caryophyllene, furfural and methyl alcohol are also present. Trace quantities of naphthalene and a bicyclic sesquiterpene alcohol may be present in the stem oil. Little or no eugenyl acetate is present.

Toxicity evaluation

The acute oral LD50 value for rats was reported as 202 g/kg with confidence limits of 1.71-2.33 g/kg (Moreno, 1974). The acute oral LD50 of clove oil was found to be 372 mg/100-g rat (von Skramlik, 1959). Clove oil was toxic to mice when applied to the skin in two doses 7 days apart (Roe & Field, 1965). The acute dermal LD50 value in rabbits was reported as > 5 g/kg (Moreno, 1974).

Pharmacology

In a pharmacological study using rat, guinea-pig and rabbit organs, clove oil was found to have antihistaminic and musculotropic spasmolytic activity (Debelmas & Rochat, 1967). Clove oil showed musculotropic (papaverine-like) antispasmodic activity against the isolated small intestine of the mouse (Imaseki and Kitabatake, 1962).