79594-11-9

Basic information

• Product Name: ((Z)-3-Methyl-hept-1-enyl)-benzene
• CAS NO: 79594-11-9
• Molecular Weight: 188.313
• Mol File: 79594-11-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ((Z)-3-Methyl-hept-1-enyl)-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: ((Z)-3-Methyl-hept-1-enyl)-benzene(79594-11-9)
• EPA Substance Registry System: ((Z)-3-Methyl-hept-1-enyl)-benzene(79594-11-9)

Safety Data

• Hazardous Substances Data: 79594-11-9(Hazardous Substances Data)

Upstream product

• 693-03-8 n-butyl magnesium bromide 
• 102918-88-7 trans-α-methyl-γ-phenylallyl pivalate 
• 52755-39-2 (2E)-1-phenylbut-2-en-1-ol 
• 36004-04-3 ethyl (E)-1-phenylbut-1-en-3-ol 
• 82045-04-3 (rac)-(E)-2-acetoxy-4-phenylbut-3-ene 
• 51801-01-5 (E)-1-acetoxy-1-phenyl-2-butene 
• 925-54-2 2-methylhexanal 
• 1100-88-5 benzyltriphenylphosphonium chloride 
• 693-04-9 butyl magnesium bromide 
• 881832-37-7 methyl 1-methyl-3-phenyl-2-propen-1-yl carbonate 
• 86668-34-0 α-methyl-γ-phenylallyl acetate 

Relevant articles and documents

Synthesis of (S)-imperanene by using allylic substitution

(Chemical Equation Presented) Synthesis of (S)-imperanene (1) was studied by using copper-assisted allylic substitution of ArCH=CHCH(L)CH2Ar (L: leaving group) and (i-PrO)Me2SiCH2MgCl. Preliminary substitution between PhCH=CHCH(L)Me (L = AcO, PivO, MeOCO2, (2-Py)CO2) and Bu copper reagents derived from BuMgX (X = Br, Cl) and CuBr·Me2S or CuCl in 1:1-40:1 ratios suggested acetate 28 as the best substrate. To prepare 28, kinetic resolution of racemic (E)-TMSCH=CHCH(OH)CH2Ar2 (Ar2 = (p-TBSO)(m-MeO)C6H3) carried out by using the asymmetric epoxidation with (-)-DIPT afforded the corresponding epoxy alcohol and (S)-allylic alcohol. After separation by chromatography, these products were converted to (S,E)-Bu3SnCH=CHCH(OH)CH2Ar2, which upon palladium-catalyzed coupling with Ar2-I followed by acetylation gave 28 (95-98% ee). Substitution of 28 with (i-PrO)Me 2SiCH2MgCl and CuBr·Me2S in a 4:1 ratio at 0°C proceeded cleanly to produce 29 with 100% inversion in 92% yield. Finally, Tamao oxidation furnished 1.

Alkylation of Allylic Derivatives. 3. The Regiochemistry of Alkylation of the Isomeric trans-α,γ-Methylphenylallyl Acetates with Lithium Dialkyleuprates

Alkylation of the isomeric trans-α,γ-methylphenylallyl acetates (1-OAc and 2-OAc) with lithium dimethylcuprate or di-n-butylcuprate is regioselective but not regiospecific.Both isomers give essentially the same product mixture which contains 95percent of the trans conjugated alkylation product (3).The starting acetates do not rearrange under the conditions for these reactions.These results show that the isomeric acetate give the same product-forming intermediate(s).Presumably the key intermediate that is common to the two isomers is a ?-allyl copper(III).