791-35-5 Usage
Description
Clofedanol, also known as (±)-chlorphedianol, is a medication with bronchodilating and antitussive properties. It is an eutectic compound, which means it is a mixture of two or more substances that are completely miscible in all proportions in the liquid state and, on cooling, form a eutectic system. Clofedanol is known for its effectiveness in treating respiratory conditions and has been utilized in the preparation of deuterated morphine derivatives for pain management and as antitussive agents with a reduced risk of drug abuse.
Uses
Used in Respiratory Applications:
Clofedanol is used as an inhalation eutectic compound for the treatment of respiratory diseases. Its bronchodilating properties help to alleviate symptoms such as shortness of breath and wheezing, making it a valuable asset in the management of conditions like asthma and chronic obstructive pulmonary disease (COPD).
Used in Pain Management:
Clofedanol is utilized in the preparation of deuterated morphine derivatives, which are useful in the treatment of pain. These derivatives offer improved pharmacokinetic properties and reduced side effects compared to traditional morphine, making them a preferred choice for pain management in various clinical settings.
Used in Antitussive Applications:
In addition to its bronchodilating and pain-relieving properties, clofedanol is also used as an antitussive agent. It helps to suppress coughing by acting on the cough center in the brain, providing relief from persistent and bothersome coughs.
Used in Pharmaceutical Industry:
Clofedanol is used as an active pharmaceutical ingredient in the development of medications for respiratory conditions, pain management, and cough suppression. Its versatility and effectiveness in these areas make it a valuable component in the pharmaceutical industry's efforts to address these health concerns.
Originator
Detigon,Bayer,W. Germany,1958
Manufacturing Process
This compound may be produced by reacting o-chlorobenzophenone with
acetonitrile in the presence of sodium amide or another strongly basic
condensing agent, to form the nitrile of beta-phenyl-beta-o-chlorophenyl-hydracrylic acid, which is then hydrogenated to yield 1-phenyl-1-o-chlorophenyl-3-aminopropanol-1. The latter intermediate compound is
subsequently dimethylated with an agent such as methyl sulfate to provide
the desired end product 1-o-chlorophenyl-1-phenyl-3-dimethylaminopropanol.
Check Digit Verification of cas no
The CAS Registry Mumber 791-35-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,9 and 1 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 791-35:
(5*7)+(4*9)+(3*1)+(2*3)+(1*5)=85
85 % 10 = 5
So 791-35-5 is a valid CAS Registry Number.
InChI:InChI=1/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3
