79083-42-4Relevant articles and documents
Unexpected furanose/pyranose equilibration of N-glycosyl sulfonamides, sulfamides and sulfamates
Suthagar, Kajitha,Polson, Matthew I. J.,Fairbanks, Antony J.
, p. 6573 - 6579 (2015)
De-protected arabino N-glycosyl sulfamides, sulfonamides and sulfamates were found to mutarotate and convert from the furanose to the thermodynamically more stable pyranose form in aqueous solution. The presence of a strongly electron withdrawing group in
Asymmetric Formal Synthesis of (-)-Swainsonine from Chiral-Pool Precursors d -Mannose and d -Arabinose
Chuanopparat, Nutthawat,Kongkathip, Boonsong,Kongkathip, Ngampong,Lamor, Anphisa,Ngernmeesri, Paiboon,Uipanit, Suwanan,Yakhampom, Sujitra
, (2022/02/23)
Carbohydrates have played an important role in organic synthesis. Since they contain many stereocenters, they have been widely used as chiral-pool starting materials. Herein, we report the asymmetric formal synthesis of (-)-swainsonine, which exhibits anticancer and immunosuppressive activities and inhibits lysosomal α-mannosidase activity, from D-mannose and D-arabinose. The synthesis utilized Zn-mediated Bernet-Vasella reaction, Horner-Wadsworth-Emmons olefination, and Grubbs olefin metathesis as key reactions.
MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF
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Page/Page column 119-121, (2021/02/19)
The present disclosure provides oligomeric compounds comprising a modified oligonucleotide having at least one stereo-non-standard nucleoside. An oligomeric compound comprising a modified oligonucleotide consisting of 12-30 linked nucleosides, wherein at least one nucleoside of the modified oligonucleotide is a stereo-non-standard nucleoside; and wherein the oligomeric compound is selected from among an RNAi compound, a modified CRISPR compound, and an artificial mRNA compound.
Preparation method of compound with 3, 4-trans-3, 6-anhydrofuran hexose structure
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Paragraph 0020, (2021/05/15)
The invention discloses a preparation method of a compound with a 3, 4-trans-3, 6-dehydrated furan hexose structure and a preparation method of the compound with the 3, 4-trans-3, 6-dehydrated furan hexose structure. The method comprises the following ste