78974-67-1 Usage
Description
CHLOROOXOACETIC ACID 4-NITROPHENYL ESTER is a chemical compound derived from chlorooxoacetic acid and 4-nitrophenol, characterized by its yellowish crystalline appearance and strong, pungent odor. It is recognized for its role as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. However, it is also noted for its high toxicity, which can lead to skin and eye irritation upon contact, and its combustibility, necessitating careful handling in well-ventilated areas.
Uses
Used in Organic Synthesis:
CHLOROOXOACETIC ACID 4-NITROPHENYL ESTER is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions, contributing to the formation of complex organic compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, CHLOROOXOACETIC ACID 4-NITROPHENYL ESTER is utilized as an intermediate, playing a crucial role in the development and manufacturing of certain medications.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, CHLOROOXOACETIC ACID 4-NITROPHENYL ESTER serves as an intermediate, aiding in the creation of products designed to enhance crop protection and management.
Check Digit Verification of cas no
The CAS Registry Mumber 78974-67-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,9,7 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 78974-67:
(7*7)+(6*8)+(5*9)+(4*7)+(3*4)+(2*6)+(1*7)=201
201 % 10 = 1
So 78974-67-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H4ClNO5/c9-7(11)8(12)15-6-3-1-5(2-4-6)10(13)14/h1-4H
78974-67-1Relevant articles and documents
Photoactivated coumaryl-diazopyruvate fluorescent label for amine functional groups of tissues containing type-I collagen
Timberlake, George T.,Reddy, G. Kesava,Stehno-Bittel, Lisa,Weber, Joerg F.,Amslinger, Sabine,Givens, Richard S.
, p. 473 - 479 (2007/10/03)
The design, synthesis and application of a new fluorescent-labeling reagent for collagen has been developed as a prerequisite for the design of a photoactivated collagen-crosslinking compound for surgical wound closure. The amine groups in collagen are the targets of a rational design for a new fluorophore because natural collagen crosslinks are formed between primary (1°) amine groups of lysine and hydroxylysine. The availability of 1° amines for crosslinking in native collagenous tissues was evaluated by reacting tendon and corneal samples with o-phthalaldehyde and dansyl chloride, fluorophores commonly used for the detection of 1° and 2° amines. The resulting fluorescent collagen fibrils indicated the presence of amines in native tissue. Subsequently, a photoactivated fluorescent label for 1° and 2° amines, coumaryl gamma-amino-butyric acid diazopyruvate (CGDP), was designed and synthesized. CGDP was first used to photolabel poly-L-lysine, forming a fluorescent, covalent bond to the 1° amine. CGDP was then photoreacted with corneal and tendon tissue samples to produce CGDP fluorescent-labeled samples that were statistically significantly more fluorescent than were the controls. These experiments support the postulate that 1° or 2° (or both) amines in native collagenous tissues are available to serve as targets for photoactivated collagen crosslinkers for wound closure.
