78454-17-8 Usage
Description
7-EPI-10-DEACETYLTAXOL is a white crystalline powder, soluble in methanol, ethanol, DMSO, and other organic solvents. It is derived from Taxus chinensis (Pilger) Rehd and is an off-white solid with chemical properties similar to paclitaxel.
Uses
Used in Pharmaceutical Industry:
7-EPI-10-DEACETYLTAXOL is used as a paclitaxel impurity and related compound B for its potential growth inhibitory activities against human cancer cells. It has been isolated from Taxus yunnanensis and is considered a promising candidate for cancer treatment research.
Used in Research and Development:
7-EPI-10-DEACETYLTAXOL is used as a reference compound in the development and testing of new anticancer drugs. Its chemical properties and potential inhibitory activities make it valuable for studying the mechanisms of action and improving the efficacy of paclitaxel-based therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 78454-17-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,4,5 and 4 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 78454-17:
(7*7)+(6*8)+(5*4)+(4*5)+(3*4)+(2*1)+(1*7)=158
158 % 10 = 8
So 78454-17-8 is a valid CAS Registry Number.
InChI:InChI=1/C45H49NO13/c1-24-29(57-41(54)35(50)33(26-15-9-6-10-16-26)46-39(52)27-17-11-7-12-18-27)22-45(55)38(58-40(53)28-19-13-8-14-20-28)36-43(5,37(51)34(49)32(24)42(45,3)4)30(48)21-31-44(36,23-56-31)59-25(2)47/h6-20,29-31,33-36,38,48-50,55H,21-23H2,1-5H3,(H,46,52)/t29-,30+,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1
78454-17-8Relevant articles and documents
Taxol Structure-Activity Relationships: Synthesis and Biological Evaluation of 10-Deoxytaxol
Chen, Shu-Hui,Fairchild, Craig,Mamber, Stephen W.,Farina, Vittorio
, p. 2927 - 2928 (2007/10/02)
10-Deoxytaxol 2 was prepared from taxol (1) in four steps via the intermediate dienone 5b; the key reaction in the sequence is a Yarovenko reagent-mediated dehydration at the C-10 hydroxyl group.Compound 2 was found to possess comparable antitumor activity with respect to taxol.This confirms that the functional group at C-10 in taxol is not involved in receptor binding.
Modified taxols. 5. Reaction of taxol with electrophilic reagents and preparation of a rearranged taxol derivative with tubulin assembly activity
Samaranayake,Magri,Jitrangsri,Kingston
, p. 5114 - 5119 (2007/10/02)
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