78172-96-0Relevant articles and documents
ALKAMIDE COMPOUNDS AND USES THEREOF
-
Page/Page column 75; 77; 82, (2019/04/27)
The present disclosure relates to alkamide compounds and compositions for treating allergic diseases, pain, or itch.
A rare earth/sodium heteroatoms double-metal complex and its preparation and use
-
Paragraph 0064; 0065, (2017/11/16)
The invention discloses a rare earth/sodium heterobimetallic complex as well as a preparation method and application thereof. The molecular formula of the rare earth/sodium heterobimetallic complex is Ln2Na8(OCH2CF3)14(THF)6, wherein Ln represents rare earth metal. The rare earth/sodium heterobimetallic complex disclosed by the invention can be applied to catalysis of the amide exchange reaction to synthesize an amide compound, the reaction conditions are mild, the catalyst dosage is relatively small, and the substrate application range is relatively wide.
N-Heterocyclic Carbene-Mediated Microfluidic Oxidative Electrosynthesis of Amides from Aldehydes
Green, Robert A.,Pletcher, Derek,Leach, Stuart G.,Brown, Richard C. D.
supporting information, p. 1198 - 1201 (2016/03/15)
A flow process for N-Heterocyclic Carbene (NHC)-mediated anodic oxidative amidation of aldehydes is described, employing an undivided microfluidic electrolysis cell to oxidize Breslow intermediates. After electrochemical oxidation, the reaction of the intermediate N-acylated thiazolium cation with primary amines is completed by passage through a heating cell to achieve high conversion in a single pass. The flow mixing regimen circumvented the issue of competing imine formation between the aldehyde and amine substrates, which otherwise prevented formation of the desired product. High yields (71-99%), productivities (up to 2.6 g h-1), and current efficiencies (65-91%) were realized for 19 amides.