77887-48-0

Basic information

• Product Name: N-ACETYL-(4R)-ISOPROPYL 2-OXAZOLIDINONE
• Synonyms: N-ACETYL-(4S)-ISOPROPYL 2-OXAZOLIDINONE;N-ACETYL-(4R)-ISOPROPYL 2-OXAZOLIDINONE;(N-Acetyl)-(R)-4-isopropyl-2-oxazolidinone;(N-Acetyl)-(S)-4-isopropyl-2-oxazolidinone;2-Oxazolidinone, 3-acetyl-4-(1-Methylethyl)-, (4S)-
• CAS NO: 77887-48-0
• Molecular Formula: C₈H₁₃NO₃
• Molecular Weight: 171.19
• Product Categories: Peptide
• Mol File: 77887-48-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 285.4±9.0 °C(Predicted)
• Appearance: /
• Density: 1.136±0.06 g/cm3(Predicted)
• PKA: -2.33±0.40(Predicted)
• CAS DataBase Reference: N-ACETYL-(4R)-ISOPROPYL 2-OXAZOLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ACETYL-(4R)-ISOPROPYL 2-OXAZOLIDINONE(77887-48-0)
• EPA Substance Registry System: N-ACETYL-(4R)-ISOPROPYL 2-OXAZOLIDINONE(77887-48-0)

Safety Data

• Hazardous Substances Data: 77887-48-0(Hazardous Substances Data)

Usage

General Description

N-ACETYL-(4R)-ISOPROPYL 2-OXAZOLIDINONE is a chemical compound with the molecular formula C9H17NO3. It is a derivative of isoniazid, an antibiotic used to treat tuberculosis, and it is used as an intermediate in the production of pharmaceuticals. N-ACETYL-(4R)-ISOPROPYL 2-OXAZOLIDINONE has a four-membered oxazolidinone ring and an isopropyl group, and it is commonly used in organic synthesis as a chiral building block, especially in the preparation of chiral drugs and drug intermediates. This chemical compound has potential applications in medicinal chemistry and pharmaceutical research due to its structural and stereochemical characteristics.

Upstream product

• 95530-58-8 (R)-4-isopropyloxazolidin-2-one 
• 75-36-5 acetyl chloride 
• 72-18-4 L-valine 
• 2026-48-4 (S)-valinol 
• 108-24-7 acetic anhydride 
• 17016-83-0 (4S)-4-isopropyl-1,3-oxazolidin-2-one 

Downstream Products

• 104672-27-7 (3'S,4S)-3-(3'-hydroxy-3'-phenylpropionyl)-4-(1-methylethyl)-2-oxazolidinone 
• 104758-27-2 (3'R,4S)-3-(3'-hydroxy-3'-phenylpropionyl)-4-(1-methylethyl)-2-oxazolidinone 

Relevant articles and documents

Oxidative asymmetric umpolung alkylation of Evans' β-ketoimides using dialkylzinc nucleophiles

Umpolung alkylation of Evans' auxiliary substituted β-ketoimides affords the diastereomerically pure products in yields ranging from 40 to 80%. The reaction itself proceeds with diastereoselectivities between 3:1 and 18:1. Dialkylzinc serves as the nucleo

Assembly intermediates in polyketide biosynthesis: Enantioselective syntheses of β-hydroxycarbonyl compounds

A versatile approach for the enantioselective synthesis of functionalised β-hydroxy N-acetylcysteamine thiol esters has been developed which allows the facile incorporation of isotopic labels. It has been shown that a remarkable reversal of selectivity occurs in the titanium mediated aldol reaction of acyloxazolidinone 7 using either (S)- or (R)-tert-butyldimethylsilyloxybutanal. The aldol products are valuable intermediates in the synthesis of 4-hydroxy-6-substituted δ-lactones. The Royal Society of Chemistry 2005.

A convenient method for synthesis of optically active methylphenidate from N-methoxycarbonylpiperidine by utilizing electrochemical oxidation and Evans aldol-type reaction

A new method to prepare optically active methylphenidate starting from piperidine is described. The method consists of a transformation of N-methoxycarbonylated piperidine to the corresponding α-methoxylated carbamate utilizing electrochemical oxidation f