7768-28-7

Basic information

• Product Name: 2-HYDROXYPHENETHYL ALCOHOL
• Synonyms: 2-(2-Hydroxyethyl)phenol;2-(2-Hydroxyphenyl)ethanol;2-(o-Hydroxyphenyl)ethanol;beta-(o-Hydroxyphenyl)ethanol;o-(2-Hydroxyethyl)phenol;o-Hydroxyphenethyl alcohol;Phenethyl alcohol, o-hydroxy-;2-HYDROXYPHENETHYL ALCOHOL
• CAS NO: 7768-28-7
• Molecular Formula: C₈H₁₀O₂
• Molecular Weight: 138.16
• EINECS: 231-863-3
• Product Categories: Alcohols;C7 to C8;Oxygen Compounds;Building Blocks;C7 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 7768-28-7.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 168-169 °C2 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear yellow to yellow-brownish/Viscous Liquid
• Density: 1.159 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.83E-05mmHg at 25°C
• Refractive Index: n20/D 1.559(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, DMSO (Slightly), Methanol (Slightly)
• Stability: Light Sensitive
• CAS DataBase Reference: 2-HYDROXYPHENETHYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYPHENETHYL ALCOHOL(7768-28-7)
• EPA Substance Registry System: 2-HYDROXYPHENETHYL ALCOHOL(7768-28-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-41-36/37/38
• Safety Statements: 26-37/39-36
• WGK Germany: 2
• Hazardous Substances Data: 7768-28-7(Hazardous Substances Data)

Usage

Description

2-Hydroxyphenethyl alcohol, also known as 2-(2-hydroxyphenyl)ethanol or 2-phenylethanol-1, is an organic compound with the chemical formula C8H10O2. It is a colorless liquid with a floral odor and is found in various plants and flowers. 2-HYDROXYPHENETHYL ALCOHOL has a hydroxyl group attached to a phenyl ring, which gives it unique chemical properties and makes it a versatile building block in organic synthesis.

Uses

Used in Chemical Synthesis:
2-Hydroxyphenethyl alcohol is used as a key intermediate in the synthesis of various organic compounds, including cyclic products and organoaluminim oligomers. Its unique structure allows for a wide range of chemical reactions, making it a valuable component in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Surface Science Research:
The inelastic electron tunneling spectra of 2-hydroxyphenethyl alcohol adsorbed on thin-film aluminum and magnesium oxide have been investigated. This research helps to understand the interactions between organic molecules and metal oxide surfaces, which is crucial for the development of advanced materials and devices, such as sensors, catalysts, and electronic components.

InChI:InChI=1/C8H10O2/c9-6-5-7-3-1-2-4-8(7)10/h1-4,9-10H,5-6H2

Upstream product

• 5339-85-5 2-aminophenethyl alcohol 
• 496-16-2 2.3-dihydrobenzofuran 
• 1091-24-3 1,1-diphenyl-2,3-dihydro-1H-benzo[b]silole 
• 18666-27-8 1-phenyl-2-(diphenylsilyl)ethane 
• 100-42-5 styrene 
• 60-12-8 2-phenylethanol 
• 108-95-2 phenol 
• 103588-71-2 (Z)-β-tert-butyldimethylsilyloxystyrene 
• 122-78-1 phenylacetaldehyde 
• 271-89-6 1-benzofurane 
• 64-17-5 ethanol 
• 553-86-6 benzofuran-2(3H)-one 
• 614-75-5 2-Hydroxyphenylacetic acid 
• 154582-38-4 2-(o-cyanomethyl)phenethyl alcohol 

Downstream Products

• 7417-18-7 2-methoxyphenethyl alcohol 
• 112998-47-7 Ameisensaeure-<2-(2-hydroxyphenyl)ethyl>ester 
• 160951-57-5 2-(2-Oxiranylmethoxy-phenyl)-ethanol 
• 658704-34-8 1-(2-methanesulfonyloxyethyl)-2-[(2-methoxyethoxy)methoxy]benzene 
• 658704-36-0 1-(2-fluoroethyl)-2-(trifluoromethanesulfonyloxy)benzene 
• 722539-65-3 2-(2-hydroxy-3-hydroxymethylphenyl)ethyllevulinate 
• 722539-66-4 2-(2-hydroxy-3-hydroxymethylphenyl)ethylpivalate 
• 722539-64-2 2-(2-hydroxy-3-hydroxymethylphenyl)ethylacetate 
• 1009068-68-1 C₉H₁₂O₄S 
• 138488-63-8 2-(2-hydroxyphenyl)ethyl pivalate 
• 722539-54-0 2-(2-hydroxyphenyl)ethyl levulinate 
• 614-75-5 2-Hydroxyphenylacetic acid 
• 174460-88-9 1-methoxy-2-(2-methoxyethyl)benzene 
• 658704-33-7 1-(2-hydroxyethyl)-2-[(2-methoxyethoxy)methoxy]benzene 

Relevant articles and documents

Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia

Therapeutic angiogenesis is a potential therapeutic strategy for hind limb ischemia (HLI); however, currently, there are no small-molecule drugs capable of inducing it at the clinical level. Activating the hypoxia-inducible factor-1 (HIF-1) pathway in skeletal muscle induces the secretion of angiogenic factors and thus is an attractive therapeutic angiogenesis strategy. Using salidroside, a natural glycosidic compound as a lead, we performed a structure-activity relationship (SAR) study for developing a more effective and druggable angiogenesis agent. We found a novel glycoside scaffold compound (C-30) with better efficacy than salidroside in enhancing the accumulation of the HIF-1α protein and stimulating the paracrine functions of skeletal muscle cells. This in turn significantly increased the angiogenic potential of vascular endothelial and smooth muscle cells and, subsequently, induced the formation of mature, functional blood vessels in diabetic and nondiabetic HLI mice. Together, this study offers a novel, promising small-molecule-based therapeutic strategy for treating HLI.

Synthesis of high added value compounds through catalytic oxidation of 2-phenylethanol: A Kinetic study

An effective procedure was developed to produce high-value added phenolic compounds through the conversion of 2-phenylethanol (2-PhEt) by using acid-activated clays KSF for the hydrogen peroxide. Owing to KSF's ability to catalyze a variety of complex oxi

PHENOLATE TRANSITION METAL COMPLEXES, PRODUCTION AND USE THEREOF

Phenolate ligands and transition metal complexes are disclosed for use in alkene polymerization, with optional chain transfer agent, to produce polyolefins.