77528-64-4

Basic information

• Product Name: ethyl 4,5,6,7-tetrahydro-2-methylbenzothiazole-5-carboxylate
• Synonyms: ethyl 4,5,6,7-tetrahydro-2-methylbenzothiazole-5-carboxylate;4,5,6,7-Tetrahydro-2-methyl-5-benzothiazolecarboxylic acid ethyl ester
• CAS NO: 77528-64-4
• Molecular Formula: C₁₁H₁₅NO₂S
• Molecular Weight: 225.3073
• EINECS: 278-710-7
• Mol File: 77528-64-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 326.6°C at 760 mmHg
• Flash Point: 151.3°C
• Appearance: /
• Density: 1.189g/cm³
• Vapor Pressure: 0.000214mmHg at 25°C
• Refractive Index: 1.545
• CAS DataBase Reference: ethyl 4,5,6,7-tetrahydro-2-methylbenzothiazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4,5,6,7-tetrahydro-2-methylbenzothiazole-5-carboxylate(77528-64-4)
• EPA Substance Registry System: ethyl 4,5,6,7-tetrahydro-2-methylbenzothiazole-5-carboxylate(77528-64-4)

Safety Data

• Hazardous Substances Data: 77528-64-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H15NO2S/c1-3-14-11(13)8-4-5-10-9(6-8)12-7(2)15-10/h8H,3-6H2,1-2H3

Upstream product

• 70590-46-4 bromo-3 oxo-2 pimelate d'ethyle 
• 42212-75-9 diethyl 2-oxopimelate 
• 94160-25-5 hydroxy-3 cyclohexane carboxylate d'ethyle 
• 7781-98-8 ethyl-3-hydroxybenzoate 
• 33668-25-6 ethyl 3-oxocyclohexanecarboxylate 
• 95211-48-6 5-(3-ethoxycarbonyl-propyl)-2-methyl-thiazole-4-carboxylic acid ethyl ester 
• 62-55-5 thioacetamide 
• 95203-29-5 bromo-4 oxo-3 cyclohexane-carboxylate d'ethyle 

Downstream Products

• 77528-67-7 methyl-2 N methylamino methyl-5 tetrahydro-4,5,6,7 benzothiazole 
• 77528-66-6 methyl-2 tosyloxymethyl-5 tetrahydro-4,5,6,7 benzothiazole 
• 77528-65-5 methyl-2 N hydroxymethyl-5 tetrahydro-4,5,6,7 benzothiazole 

Relevant articles and documents

Synthesis of aminoderivatives of 4,5,6,7-tetrahydro-benzothiazole. I. 4,5,6- and 7-amino and N-methyl amino derivatives with central dopaminergic activity

4-Oxo and 6-oxo-4,5,6,7-tetrahydro-benzothiazoles were prepared from diester derivatives of thiazole through Dieckmann cyclisation. The 7-oxo compound was synthesized by formation of a thiazole ring on 2-bromo-1,3-cyclohexanedione. The ketones were tranformed into amines and N-methylamines by reductive amination. The 5-amino derivatives were obtained by Hofmann reaction of the corresponding amides. The amines and N-methylamines in the 6-position have central dopaminergic properties. Their isomers in the 4, 5 or 7 positions are inactive.

4,5 or 6-Alkylaminoalkyl-2-alkyl-4,5,6,7-tetrahydro benzo[d]thiazoles

This invention relates to compounds of the formula (I): STR1 in which: R is selected from hydrogen and C1-6 alkyl and R' is selected from hydrogen and C1-6 alkyl; and their pharmaceutically acceptable acid addition salts. Said compounds are therapeutically useful for the treatment of circulatory insufficiencies.