77458-01-6 Usage
Description
Pyraclofos is an organophosphate insecticide and acaricide, characterized by its broad-spectrum activity against various pests. It is effective in controlling Lepidoptera, Coleoptera, mites, and nematodes, making it a versatile choice for agricultural and horticultural applications.
Uses
Used in Agricultural and Horticultural Industries:
Pyraclofos is used as a pesticide for controlling Lepidoptera, Coleoptera, mites, and nematodes in fruit, vegetables, ornamentals, and forestry. Its broad-spectrum activity allows for effective pest management, protecting crops and plants from damage and ensuring a healthy yield.
Used in Human Health Applications:
Pyraclofos is also used as an anthelmintic agent for controlling filarial worms in human health applications. Its ability to target and eliminate these parasitic worms contributes to the prevention and treatment of related diseases, improving overall public health.
Metabolic pathway
Pyraclofos is apparently subjected in insects to a metabolic activation to
yield a more active acetylcholinesterase inhibitor which is possibly a
thiooxidized metabolite. The compound is very rapidly degraded in
mammals to inactive metabolites via P-O-aryl, P-O-alkyl and P-S-alkyl
cleavage which explains its favourable selective toxicity. In both mammals
and plants the principal degradative route is via P-O-aryl cleavage to
give 1-(4-chlorophenyl)-4-hydroxypyrazolwe hich is rapidly conjugated.
Metabolism
Pyraclofos
is metabolized to an active AChE inhibitor, probably by
the oxidation of the sulfur atom in the phosphorothiolate
linkage. The half-life in soil is 3–38 d, depending on
soil type.
Toxicity evaluation
The acute oral LD50 for
rats is 237 mg/kg. The inhalation LC50 for rats is
1.69 mg/L air. NOEL (2 yr) for rats is 0.10–0.12 mg/kg
diet (0.005–0.006 mg/kg/d). Pyraclofos administered to
rats is rapidly degraded, and more than 90% of the
dose is excreted principally in the urine within 24 h. The
degradation routes are cleavages of the P?S, P?O-alkyl,
and P?O-aryl bonds in both animals and plants.
Degradation
The DT50 for hydrolysis in water at pH 7 (25 °C) was 29 days (PM).
Check Digit Verification of cas no
The CAS Registry Mumber 77458-01-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,4,5 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 77458-01:
(7*7)+(6*7)+(5*4)+(4*5)+(3*8)+(2*0)+(1*1)=156
156 % 10 = 6
So 77458-01-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H18ClN2O3PS/c1-3-9-22-21(18,19-4-2)20-14-10-16-17(11-14)13-7-5-12(15)6-8-13/h5-8,10-11H,3-4,9H2,1-2H3
77458-01-6Relevant articles and documents
Pyrazol-4-yl phosphites
-
, (2008/06/13)
A 4-pyrazolyl phosphorous acid ester of the following formula, STR1 (R is a lower alkyl group; Y is a phenyl group which may optionally be substituted by a halogen, halogens, a lower alkyl group or a halogen and a lower alkyl group.) which is produced by reacting corresponding 4-hydroxylpyrazole compound with a trialkyl phosphite. The ester gives 4-pyrazolyl phosphorothioate by the reaction with an alkylsulfenyl halide.