774212-81-6

Basic information

• Product Name: Carbamic acid, [(1R,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [(1R,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI);(1R,3S)-3-AMino-1-(Boc-aMino)cyclopentane;Carbamic acid, N-[(1R,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester;tert-Butyl ((1R,3S)-3-aminocyclopentyl)carbamate;tert-butyl N-[(1R,3S)-3-aminocyclopentyl]carbamate;((1R,3S)-3-Aminocyclopentyl)carbamic acid tert-butyl ester
• CAS NO: 774212-81-6
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 200.278
• Product Categories: CYCLOPENTANE;N-BOC
• Mol File: 774212-81-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 304.2±31.0 °C(Predicted)
• Appearance: /
• Density: 1.04±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.37±0.40(Predicted)
• CAS DataBase Reference: Carbamic acid, [(1R,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI)(774212-81-6)
• EPA Substance Registry System: Carbamic acid, [(1R,3S)-3-aminocyclopentyl]-, 1,1-dimethylethyl ester (9CI)(774212-81-6)

Safety Data

• Hazardous Substances Data: 774212-81-6(Hazardous Substances Data)

Usage

Uses

tert-Butyl ((1R,3S)-3-Aminocyclopentyl)carbamate is used as a reactant in the synthesis of C-2 hydroxyethyl imidazopyrrolo pyridines as JAK1 inhibitors.

Upstream product

• 261165-05-3 (1S,3R)-3-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid 
• 774212-79-2 ((1R,3S)-3-benzyloxycarbonylamino-cyclopentyl)-carbamic acid tert-butyl ester 

Downstream Products

• 1418200-43-7 [(1R,3S)-3-(5-amino-1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclopentyl]-carbamic acid tert-butyl ester 
• 1418200-21-1 ((1R,3S)-3-[6-benzenesulfonyl-2-((R)-1-hydroxyethyl)-6H-1,3,5,6-tetraaza-as-indacen-1-yl]-cyclopentyl)-carbamic acid tert-butyl ester 
• 1418200-22-2 (R)-1-[1-((1S,3R)-3-amino-cyclopentyl)-6-benzenesulfonyl-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl]-ethanol 
• 1418200-23-3 (R)-1-(6-benzenesulfonyl-1-[(1S,3R)-3-(2,2,2-trifluoro-ethylamino)-cyclopentyl]-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl)-ethanol 
• 1418200-24-4 (R)-1-(6-benzenesulfonyl-1-[(1S,3R)-3-(2,2-difluoro-ethylamino)-cyclopentyl]-1,6-dihydro-1,3,5,6-tetraaza-as-indacen-2-yl)-ethanol 
• 1315495-85-2 [(1R,3S)-3-( 1-benzenesulfonyl-5-nitro-1H-pyrrolo[2,3-b]pyridin-4-ylamino)-cyclopentyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Solid dispersions containing an apoptosis-inducing agent

A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

POLYCYCLIC COMPOUNDS AS INHIBITORS OF BRUTON'S TYROSINE KINASE

The present disclosure is directed to compounds of Formula (I) as Bruton's kinase inhibitors and their preparation, as well as compositions comprising compounds of Formula (I).

FUSED TRICYCLIC COMPOUNDS FOR USE AS INHIBITORS OF JANUS KINASES

The invention provides novel compounds of formula (I) having the general formula (I) wherein R1, V, W, X, Y and Z are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders.