770-12-7Relevant articles and documents
Prodrug compound and application ofprodrug compound in treatment of cancer
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Paragraph 0140-0141, (2021/03/06)
The present invention provides a compound indicated by a formula (I), pharmaceutically acceptable salts or esters thereof, a pharmaceutical composition of the compound, and application of the compoundand the pharmaceutical composition in the inhibition or regulation of the activity of tyrosine kinase and treating disease symptoms or symptoms including cancer mediated by tyrosine kinase.
Organophosphorous phenyl phosphates: Synthesis, dye/protein interactions and antimicrobial evaluation
Ameta, Rakesh Kumar,Duan, Yongtao,Koshti, Rohit R.,Muddassir, Mohd.,Patel, Amee S.,Trivedi, Nidhi S.,Vyas, Akshay
, (2021/01/09)
A series of Phenyl Phosphates (PPs) has been synthesized and characterized with FTIR spectroscopy. PPs, the product of the reaction of phenol and phosphoryl chloride followed by hydrolysis having larger number of hydrophilic hydroxyl groups, used for the dye interaction and antimicrobial activities. Interaction of PPs with 1,2-diphenyldiazene and 4-(phenyldiazene)phenol were studied through UV/ Vis method where observed hypochromic effect has revealed the dye adsorption property of PPs. Similarly PPs have shown the interaction with bovine serum and human serum albumins where the weaker interaction observed with later. Antimicrobial in vitro evaluation has been assessed on the basis of zone of inhibition with six bacterial (gram +ve and –ve) strains. Since PPs were found very active so minimal inhibitory concentration (MIC) analysis was done where all PPs have shown MIC less than 5 μg/mL. Due to high number of hydroxyl groups PPs have shown good interactions with biomolecules and cell wall of bacteria therefore this impression has predicted their future in medicinal field.
Preparation method of pentaerythritol diphosphate
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Paragraph 0032; 0044-0045; 0047-0048; 0050-0051, (2020/09/12)
The invention relates to the technical field of organic synthesis, and provides a preparation method of pentaerythritol diphosphate. The phosphoryl dichloride compound is prepared from a phenolic compound and phosphorus oxychloride under the condition of a catalyst, the yield of the phosphoryl dichloride compound is high, the activity of the phosphoryl dichloride compound is high, and the next step of reaction can be directly carried out without drying; then the phosphoryl dichloride compound is reactd with pentaerythritol under the vacuum pressure reduction condition, acid generated in the reaction can be rapidly removed under the vacuum pressure reduction condition, and the reaction can be carried out in the forward direction; furthermore, a phosphoryl dichloride compound is dropwise added, after dropwise adding is completed, esterification can be completed basically by one acyl chloride, and at the moment, an acid-binding agent is added, so that esterification of a second acyl chloride is facilitated, and the reaction time is greatly shortened; and the reaction temperature can be reduced under the vacuum decompression condition, the problems of acidolysis of pentaerythritol diphosphate and reaction with hydrogen chloride are avoided, the reaction safety and operability are improved, and the reaction efficiency is improved.