7681-57-4 Usage
Chemical Description
Sodium metabisulfite is an inorganic compound used as a disinfectant, antioxidant, and preservative.
Description
Sodium metabisulfite (chemical formula: Na2S2O5) is a white crystalline or powder solid with a slight sulfur odor. It is toxic upon inhalation and can strongly irritate skin and tissue. It can be decomposed to release toxic oxide fumes of sulfur and sodium upon high temperature. It can be mixed with water to form a corrosive acid. It is generally used as a disinfectant, antioxidant, and preservative agent, as well as a laboratory reagent.
Used in Pulp and Paper Industry:
Sodium metabisulfite is used as a bleach or dechlorinator for improving the quality of paper products.
Used in Photographic Industry:
Sodium metabisulfite is used as a preservative in photo developer solutions, enhancing the stability and performance of photographic materials.
Used in Food Industry:
Sodium metabisulfite is used as a food preservative to maintain the freshness, flavor, and color of various food products and wines.
Used in Chemical Production:
Sodium metabisulfite is used in the manufacture of other chemicals, cleaning agents, detergents, and soaps, contributing to their effectiveness and quality.
Used in Oil and Gas Industry:
Sodium metabisulfite acts as a corrosion inhibitor, protecting equipment and infrastructure from corrosion and extending their lifespan.
Used in Gold Mining Industry:
Sodium metabisulfite is utilized in the precipitation of gold from auric acid and in wastewater treatment to remove hexavalent chromium as trivalent chromium by precipitation after reduction.
Used in Wastewater Treatment:
Sodium metabisulfite plays as an oxygen scavenger to eliminate dissolved oxygen in wastewater and pipes, improving water quality and preventing corrosion.
Used in Polymerization Process:
Sodium metabisulfite may be used as an initiator during the cross-linking polymerization of polybutadiene in the cores of vesicle membranes, enhancing the properties of the final product.
Used in Pharmaceutical Studies:
Sodium metabisulfite may be added as an antioxidant during the preparation of stock solutions of 6-hydroxydopamine in various studies, ensuring the stability and effectiveness of the solutions.
Used in Dechlorination:
Sodium metabisulfite is used for dechlorination in municipal wastewater, pulp & paper, power, and textile water treatment plants, improving water quality and safety.
Used in Dried Fruits:
Sodium metabisulfite is used to preserve flavor, color, and inhibit undesirable microorganism growth in dried fruits.
Used in Shrimp Processing:
Sodium metabisulfite prevents "black spots" due to oxidative deterioration in shrimp, maintaining their quality and appearance.
Used in Maraschino Cherries:
Sodium metabisulfite is used in maraschino cherries to preserve their color and freshness.
Used in Lemon Drinks:
Sodium metabisulfite is found in lemon drinks as a preservative, maintaining their quality and safety.
Used as a Pharmaceutic Aid:
Sodium metabisulfite is used as an antioxidant in the pharmaceutical industry, improving the stability and effectiveness of various medications.
Preparation
manufactures sodium metabisulfite by reacting sulfur dioxide with sodium carbonate (soda ash), purifying and drying to form crystals or powder.
Na2CO3 + 2SO2→Na2S2O5 + CO2
Product Specification
▼▲
Sodium Metabisulfite, wt%
98.7% min.
Assay as SO2
66.5 min.
Insolubles, wt%
≤ 0.005
Chloride, wt%
≤ 0.05
Thiosulfate, wt%
≤ 0.05
Arsenic, ppm
≤ 1.0
Heavy metals, ppm
≤ 10.0
Iron as (Fe), ppm
≤ 2.0
Selenium, ppm
≤ 5.0
Lead as (Pb), ppm
≤ 2.0
Health Hazard
Sodium metabisulphite is currently listed in Annex III Part B of Directive 95/2/EC as an authorised food additive. As such food labelling is required where sulphite residues exceed 10 mg/kg (ppm). This is labelled E223 with maximum permitted residues in crustacean products set at 150 mg/kg. However it is now accepted that sulphites, when present in foodstuffs, can cause allergic reactions in vulnerable persons and can constitute a danger to health (Collins-Williams, 1983). Metabisulphite is regarded as one causative agent of asthma attacks (Gunnison & Jacobsen, 1987). In accordance with this, EU Directive 2003/89/EC will make allergen labelling a requirement for all food stuffs produced in the European Community, which have been treated with sodium metabisulphite.
Sodium metabisulfite typically found in consumer products should pose little a risk of symptoms due to skin or inhalation exposure since sodium metabisulfite is used in very low concentrations. Sodium metabisulfite can produce the following adverse health affects:
Contact - Skin exposures can cause symptoms ranging from minor skin irritation or itching to redness and swelling. Eye exposure to sodium metabisulfite may result in redness, tearing or moderate eye irritation.
Inhalation - The inhalation of sodium metabisulfite dusts can cause nose and throat irritation or coughing. Repeated or prolonged exposures may cause sore throat or nosebleeds. Inhalation may also cause severe respiratory reactions and aggravate asthma or other breathing diseases.
Ingestion - The ingestion of sodium metabisulfite may cause irritation of the mouth and throat, nausea, vomiting and diarrhea.
Other Effects - The International Agency for Research on Cancer (IARC) has not classified sodium metabisulfite as a carcinogen (cancer causing).
Health Hazard
Sodium metabisulfite may cause
bronchospasm, oculonasal symptoms, and
urticaria in sulfite-sensitive individuals; irritation
of mucous membranes may occur from
inhalation of the dust.
References
http://msdssearch.dow.com/PublishedLiteratureDOWCOM/dh_004f/0901b8038004f697.pdf
https://en.wikipedia.org/wiki/Sodium_metabisulfite
https://pubchem.ncbi.nlm.nih.gov/compound/Sodium_metabisulfite#section=Metabolism-Metabolites
Production Methods
Sodium metabisulfite is prepared by saturating a solution of sodium
hydroxide with sulfur dioxide and allowing crystallization to occur;
hydrogen is passed through the solution to exclude air. Sodium
metabisulfite may also be prepared by saturating a solution of
sodium carbonate with sulfur dioxide and allowing crystallization
to occur, or by thermally dehydrating sodium bisulfite.
Hazard
Toxic by inhalation. Upper respiratory tract
irritant. Questionable carcinogen.
Flammability and Explosibility
Nonflammable
Pharmaceutical Applications
Sodium metabisulfite is used as an antioxidant in oral, parenteral,
and topical pharmaceutical formulations, at concentrations of
0.01–1.0% w/v, and at a concentration of approximately 27% w/v
in intramuscular injection preparations. Primarily, sodium metabisulfite
is used in acidic preparations; for alkaline preparations,
sodium sulfite is usually preferred. Sodium
metabisulfite also has some antimicrobial activity, which is greatest
at acid pH, and may be used as a preservative in oral preparations
such as syrups.
In the food industry and in wine production, sodium metabisulfite
is similarly used as an antioxidant, antimicrobial preservative,
and antibrowning agent. However, at concentrations above
about 550 ppm it imparts a noticeable flavor to preparations.
Sodium metabisulfite usually contains small amounts of sodium
sulfite and sodium sulfate.
Contact allergens
This agent is frequently used as a preservative in pharmaceutical products, in the bread-making industry as an antioxidant, and it can induce contact dermatitis. It can be used as a reducing agent in photography and caused dermatitis in a photographic technician, probably acting as an aggravating irritative factor. Sodium metabisulfite contains a certain amount of sodium sulfite and sodium sulfate.
Safety Profile
An inhalation hazard. Poison by intravenous route. Moderately toxic by parenteral route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and Na2O.
Safety
Sodium metabisulfite is widely used as an antioxidant in oral,
topical, and parenteral pharmaceutical formulations; it is also
widely used in food products.
Although it is extensively used in a variety of preparations,
sodium metabisulfite and other sulfites have been associated with a
number of severe to fatal adverse reactions. These are usually
hypersensitivity-type reactions and include bronchospasm and
anaphylaxis. Allergy to sulfite antioxidants is estimated to occur
in 5–10% of asthmatics, although adverse reactions may also occur
in nonasthmatics with no history of allergy.
Following oral ingestion, sodium metabisulfite is oxidized to
sulfate and is excreted in urine. Ingestion may result in gastric
irritation, owing to the liberation of sulfurous acid, while ingestion
of large amounts of sodium metabisulfite can cause colic, diarrhea,
circulatory disturbances, CNS depression, and death.
In Europe, the acceptable daily intake of sodium metabisulfite
and other sulfites used in foodstuffs has been set at up to 3.5 mg/kg
body-weight, calculated as sulfur dioxide (SO2). The WHO has
similarly also set an acceptable daily intake of sodium metabisulfite,
and other sulfites, at up to 7.0 mg/kg body-weight, calculated as
sulfur dioxide (SO2).
LD50 (rat, IV): 0.12 g/kg
Potential Exposure
Sodium metabisulfite is used as an antioxidant in pharmaceutical preparations and as a preservative in foods. People with asthma have a greater chance of having an allergic reaction with this chemical. Individuals allergic to sodium bisulfite (a food preservative found in some wine, fresh shrimp; packaged foods; and restaurant salads and potatoes) may have a severe reaction when exposed to sodium metabisulfite.
Carcinogenicity
Sodium metabisulfite was genotoxic in
mice in vivo as determined by chromosomal
aberration, micronucleus, and sperm shape
assays. It was not mutagenic in bacterial
assays.
storage
On exposure to air and moisture, sodium metabisulfite is slowly
oxidized to sodium sulfate with disintegration of the crystals.
Addition of strong acids to the solid liberates sulfur dioxide.
In water, sodium metabisulfite is immediately converted to
sodium (Na+) and bisulfite (HSO3-) ions. Aqueous sodium
metabisulfite solutions also decompose in air, especially on heating.
Solutions that are to be sterilized by autoclaving should be filled into
containers in which the air has been replaced with an inert gas, such
as nitrogen. The addition of dextrose to aqueous sodium
metabisulfite solutions results in a decrease in the stability of the
metabisulfite.
The bulk material should be stored in a well-closed container,
protected from light, in a cool, dry place.
Shipping
UN1759 Corrosive solids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name required. UN2693 Bisulfites, inorganic, aqueous solutions, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.
Incompatibilities
Sodium metabisulfite reacts with sympathomimetics and other
drugs that are ortho- or para-hydroxybenzyl alcohol derivatives to
form sulfonic acid derivatives possessing little or no pharmacological
activity. The most important drugs subject to this inactivation
are epinephrine (adrenaline) and its derivatives. In addition,
sodium metabisulfite is incompatible with chloramphenicol owing
to a more complex reaction; it also inactivates cisplatin in
solution.
It is incompatible with phenylmercuric acetate when autoclaved
in eye drop preparations.
Sodium metabisulfite may react with the rubber caps of
multidose vials, which should therefore be pretreated with sodium
metabisulfite solution.
Incompatibilities
A strong reducing agent. Keep away from oxidizers. Mixtures with water forms a strong corrosive. Contact with acids releases toxic fumes. Heat causes decomposition. Slowly oxidized to the sulfate on exposure to air and moisture. Attacks metals
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (epidural;inhalation; IM and IV injections; ophthalmic solutions; oral
preparations; rectal, topical, and vaginal preparations). Included
in nonparenteral and parenteral medicines licensed in the UK.
Included in the Canadian List of Acceptable Non-medicinal
Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 7681-57-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,6,8 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 7681-57:
(6*7)+(5*6)+(4*8)+(3*1)+(2*5)+(1*7)=124
124 % 10 = 4
So 7681-57-4 is a valid CAS Registry Number.
InChI:InChI=1/2Na.H2O5S2/c;;1-6(2)7(3,4)5/h;;(H,1,2)(H,3,4,5)/q2*+1;/p-2
