767618-90-6

Basic information

• Product Name: N-(4-{2-[2-(4-nitro-phenyl)-ethylamino]-ethoxy}-phenyl)-methanesulfonamide
• Synonyms: N-(4-{2-[2-(4-nitro-phenyl)-ethylamino]-ethoxy}-phenyl)-methanesulfonamide
• CAS NO: 767618-90-6
• Molecular Weight: 379.437
• Mol File: 767618-90-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-{2-[2-(4-nitro-phenyl)-ethylamino]-ethoxy}-phenyl)-methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-{2-[2-(4-nitro-phenyl)-ethylamino]-ethoxy}-phenyl)-methanesulfonamide(767618-90-6)
• EPA Substance Registry System: N-(4-{2-[2-(4-nitro-phenyl)-ethylamino]-ethoxy}-phenyl)-methanesulfonamide(767618-90-6)

Safety Data

• Hazardous Substances Data: 767618-90-6(Hazardous Substances Data)

Upstream product

• 69447-84-3 p-nitrophenethylamine hydrobromide 

Downstream Products

• 705248-62-0 N-[2-(4-methanesulfonylamino-phenoxy)-ethyl]-N-[2-(4-nitro-phenyl)-ethyl]-acetamide 
• 226992-16-1 N-[4-(2-{benzyl-[2-(4-methanesulfonylamino-phenoxy)-ethyl]-amino}-ethyl)-phenyl]-methanesulfonamide 
• 312315-39-2 N-[4-(2-{[2-(4-amino-phenyl)-ethyl]-benzyl-amino}-ethoxy)-phenyl]-methanesulfonamide 
• 312315-40-5 N-[2-(4-amino-phenyl)-ethyl]-N-[2-(4-methanesulfonylamino-phenoxy)-ethyl]-acetamide 
• 312315-41-6 N-[4-(2-{allyl-[2-(4-amino-phenyl)-ethyl]-amino}-ethoxy)-phenyl]-methanesulfonamide 
• 115256-12-7 1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-aminophenethyl)amino]ethane 
• 115256-11-6 dofetilide 
• 732975-69-8 N-[4-(2-{allyl-[2-(4-nitro-phenyl)-ethyl]-amino}-ethoxy)-phenyl]-methanesulfonamide 
• 751470-16-3 N-[4-(2-{benzyl-[2-(4-nitro-phenyl)-ethyl]-amino}-ethoxy)-phenyl]-methanesulfonamide 
• 115256-44-5 1-(4-methanesulphonamidophenoxy)-2-[N-methyl-N-(4-nitrophenethyl)amino]ethane 

Relevant articles and documents

Computer-aided design, synthesis and biological assay of p-methylsulfonamido phenylethylamine analogues

Class III antiarrhythmic agents selectively delay the effective refractory period (ERP) and increase the transmembrance action potential duration (APD). Based on our previous studies, a set of 17 methylsulfonamido phenylethylamine analogues were investigated by 3D-QSAR techniques of CoMFA and CoMSIA. The 3D-QSAR models proved a good predictive ability, and could describe the steric, electrostatic and hydrophobic requirements for recognition forces of the receptor site. According to the clues provided by this 3D-QSAR analysis, we designed and synthesized a series of new analogues of methanesulfonamido phenylethylamine (VI(a-i)). Pharmacological assay indicated that the effective concentrations of delaying the functional refractory period (FRP) 10ms of these new compounds have a good correlation with the 3D-QSAR predicted values. It is remarkable that the maximal percent change of delaying FRP in μM of compound VI(c) is much higher than that of dofetilide. The results showed that the 3D-QSAR models are reliable. (C) 2000 Elsevier Science Ltd.