75933-85-6

Basic information

• Product Name: Phosphoric acid 2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(tetrahydro-pyran-2-yloxy)-ethyl ester 5-chloro-quinolin-8-yl ester
• Synonyms: Phosphoric acid 2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(tetrahydro-pyran-2-yloxy)-ethyl ester 5-chloro-quinolin-8-yl ester
• CAS NO: 75933-85-6
• Molecular Weight: 933.351
• Mol File: 75933-85-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phosphoric acid 2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(tetrahydro-pyran-2-yloxy)-ethyl ester 5-chloro-quinolin-8-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphoric acid 2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(tetrahydro-pyran-2-yloxy)-ethyl ester 5-chloro-quinolin-8-yl ester(75933-85-6)
• EPA Substance Registry System: Phosphoric acid 2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(tetrahydro-pyran-2-yloxy)-ethyl ester 5-chloro-quinolin-8-yl ester(75933-85-6)

Safety Data

• Hazardous Substances Data: 75933-85-6(Hazardous Substances Data)

Upstream product

• 130-16-5 5-Chloro-8-hydroxyquinoline 
• 77181-80-7 Phosphorochloridic acid 4-chloro-phenyl ester 5-chloro-quinolin-8-yl ester 
• 81366-72-5 4-chlorophenyl 5-chloro-8-quinolyl hydrogen phosphate 
• 69359-38-2 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylcytidine 
• 77181-81-8 4-chlorophenyl 5-chloro-8-quinolyl phosphorotetrazolide 
• 75933-81-2 5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylcytidine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate) 
• 772-79-2 4-chlorophenylphosphorodichloridate 

Relevant articles and documents

A Convenient Synthesis of the 3'-Terminal Nonaoligoribonucleotide of Rous Sarcoma Virus 35S RNA via the Modified Phosphotriester Approach

The synthesis of oligoribonucleotide UpUpCpApCpCpApCpA via the phosphotriester approach, which is located at the 3'terminus of Rous sarcoma virus 35S RNA, is described. 5'-O-(Dimethoxytrityl)-2'-O-tetrahydropyranyl-N-acylnucleoside 3'-(4-chlorophenyl 5-chloro-8-quinolyl phosphates) were used as the starting materials .Treatment of the fully protected mononucleotides with 2percent p-toluenesulfonic acid afforded the 5'-hydroxyl nucleotides, whereas treatment with syn-pyridine-2-carboxaldoxime to remove the 4-chlorophenyl group gave the phosphodiesters.The fully protected nona mer was prepared by utilizing these deblocking products.The fully protected nonamer was completely deprotected by treatment with zinc chloride, followed by treatment with base and acid, to give the corresponding oligoribonucleotide.

(8-Quinolinesulfonyl)tetrazole: A New Type of Highly Efficient Coupling Agent for the Synthesis of Ribooligonucleotides by the Phosphortriester Approach

(8-Quinolinesulfonyl)Tetrazole (QS-tet) has been developed as a new type of highly efficient coupling agent in the synthesis of phosphotriester bonds.This reagent very rapidly completes the coupling reactions, and the yield is considerably higher than tha