7500-45-0

Basic information

• Product Name: N-Benzylbenzeneacetamide
• Synonyms: N-Benzyl-2-phenylacetamide;N-Benzylbenzeneacetamide;N-Benzylphenylacetamide;BenzeneacetaMide, N-(phenylMethyl)-
• CAS NO: 7500-45-0
• Molecular Formula: C₁₅H₁₅NO
• Molecular Weight: 225.29
• Mol File: 7500-45-0.mol
• Article Data: 231

Chemical Properties

• Boiling Point: 446.9°C at 760 mmHg
• Flash Point: 268.9°C
• Appearance: /
• Density: 1.096g/cm³
• Vapor Pressure: 3.5E-08mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: N-Benzylbenzeneacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzylbenzeneacetamide(7500-45-0)
• EPA Substance Registry System: N-Benzylbenzeneacetamide(7500-45-0)

Safety Data

• Hazardous Substances Data: 7500-45-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 57, p. 6101, 1992 DOI: 10.1021/jo00049a009

InChI:InChI=1/C15H15NO/c17-15(11-13-7-3-1-4-8-13)16-12-14-9-5-2-6-10-14/h1-10H,11-12H2,(H,16,17)

Upstream product

• 100-39-0 benzyl bromide 
• 77287-34-4 formamide 
• 151-50-8 potassium cyanide 
• 100-44-7 benzyl chloride 
• 3626-62-8 2-phenyl-1-(1-piperidinyl)ethanone 
• 100-46-9 benzylamine 
• 1788-31-4 1,3-diphenylpropan-2-one oxime 
• 58377-03-0 N-benzyl-2-phenylethanethioamide 
• 103-82-2 phenylacetic acid 
• 62-53-3 aniline 
• 65439-58-9 2-phenyl-1-(2-thioxothiazolidin-3-yl)ethan-1-one 
• 28481-53-0 2-hydroxyethyl 2-phenylacetate 
• 101-94-0 p-tolyl phenylacetate 
• 2078-18-4 trimethylsilyl 2-phenylacetate 

Downstream Products

• 85909-01-9 Benzyl-phenylacetyl-carbamic acid tert-butyl ester 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 85-01-8 phenanthrene 
• 100-52-7 benzaldehyde 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 108-88-3 toluene 
• 100-46-9 benzylamine 
• 112157-94-5 Acetic acid N'-benzyl-N'-phenylacetyl-hydrazide 
• 102-16-9 benzyl 2-phenylacetate 
• 101-97-3 Ethyl 2-phenylethanoate 
• 63418-51-9 N-Benzyl-α-phenylselenoacetamide 
• 862906-94-3 3-chloro-4-phenyl-1-(phenylmethyl)-1H-pyrrole-2,5-dione 
• 264206-85-1 GSK₃₉₈₇ 
• 103-82-2 phenylacetic acid 

Relevant articles and documents

Recyclization reactions of 1-alkylpyrimidinium salts

The reaction of 4-amino-2-benzyl-1-methyl-5-ethoxycarbonylpyrimidinium iodide ( 3 ) with alcoholic methylamine resulted in the formation of the methylimine of 2-amino-4- hydroxy-6-methylamino-5-phenylpyridine-3-carbaldehyde ( 5 ). Heating of the same pyri

Model experiments for peptide fragment coupling without racemization-prone activated amino acid derivatives.

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Reductive N-alkylation of primary amides using nickel-nanoparticles

Here we report Ni-nanoparticles as reusable catalysts for reductive N-alkylation of amides. These Ni-nanoparticles based catalysts have been prepared by the template synthesis of tartaric acid and 2-methyl imidazole ligated Ni-complex on SiO2 and subsequent pyrolysis under argon. Applying optimal Ni-nanostructured catalyst, N-alkylation of aromatic and heterocyclic primary amides with different aldehydes in presence of molecular hydrogen was performed to access structurally diverse N-alkylated amides in good to excellent yields. In addition, the applicability of this N-alkylation protocol has been demonstrated for the selective functionalization of primary amide group in Levetiracetam drug.

Efficient and accessible silane-mediated direct amide coupling of carboxylic acids and amines

A straightforward method for the direct synthesis of amides from amines and carboxylic acids without exclusion of air or moisture using diphenylsilane with N-methylpyrrolidine has been developed. Various amides are made efficiently, and broad functional group compatibility is shown through a Glorius robustness study. A gram-scale synthesis demonstrates the scalability of this method. This journal is