74839-84-2 Usage
Description
(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE, also known as (2R,3R)-Bis(diphenylphosphino)butane, is a white crystalline powder with unique chemical properties. It is a valuable reagent in the field of organic chemistry, particularly for the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Synthesis:
(2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE is used as a reagent for the synthesis of endothelin A receptor antagonists, which are important in the treatment of various cardiovascular and cerebrovascular diseases. Its chiral nature allows for the selective synthesis of these compounds, contributing to the development of more effective medications.
Used in Synthesis of (R)-Tolterodine and (S)-Tolterodine:
In the pharmaceutical industry, (2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE is utilized as a key reagent in the synthesis of (R)-Tolterodine and (S)-Tolterodine. These compounds are used as active ingredients in medications for treating overactive bladder and urinary incontinence, providing relief to patients suffering from these conditions.
Chemical Properties:
As a white crystalline powder, (2R,3R)-(+)-BIS(DIPHENYLPHOSPHINO)BUTANE exhibits distinct chemical properties that make it suitable for use in various chemical reactions and processes. Its diphenylphosphino groups contribute to its reactivity and selectivity, making it a preferred choice for specific applications in the pharmaceutical industry.
Purification Methods
It recrystallises from absolute EtOH (~6g in 60mL) as colourless plates [Fryzuk & Bosnich J Am Chem Soc 99 6262 1977, Fryzuk & Bosnich J Am Chem Soc 101 3043 1979].
Check Digit Verification of cas no
The CAS Registry Mumber 74839-84-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,8,3 and 9 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 74839-84:
(7*7)+(6*4)+(5*8)+(4*3)+(3*9)+(2*8)+(1*4)=172
172 % 10 = 2
So 74839-84-2 is a valid CAS Registry Number.
InChI:InChI=1/C28H28P2/c1-23(29(25-15-7-3-8-16-25)26-17-9-4-10-18-26)24(2)30(27-19-11-5-12-20-27)28-21-13-6-14-22-28/h3-24H,1-2H3/t23-,24-/m1/s1
74839-84-2Relevant articles and documents
Highly Active and Selective Ethylene Oligomerization Catalyst and Method of Preparing Hexene or Octene Using the Same
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Page/Page column 8, (2012/06/01)
This invention relates to a chromium complex compound for selective ethylene oligomerization including a chiral ligand, and to a method of selectively preparing 1-hexene or 1-octene from ethylene using the same.
Synthesis of the chiral diphosphine ligand 2,3-bis(diphenylphosphino)butane (CHIRAPHOS)
Matteoli, Ugo,Beghetto, Valentina,Schiavon, Cristina,Scrivanti, Alberto,Menchi, Gloria
, p. 1403 - 1409 (2007/10/03)
A new synthesis of CHIRAPHOS starting from readily available 2,3-bis(diphenylphosphinyl)- 1,3-butadiene has been devised. The key step of the synthesis is the hydrogenation of the diene to rac-2,3-bis(diphenylphosphinyl)butane. This reduction can be conve