74805-91-7 Usage
Description
(3R)-2,3-Dihydro-5,7-dihydroxy-3-[(4-methoxyphenyl)methyl]-6,8-dimethyl-4H-1-benzopyran-4-one, also known as Methylophiopogonanone B, is a natural compound derived from the roots of Ophiopogon japonicus, a traditional Chinese medicinal plant. It is characterized by its unique chemical structure, featuring a 1-benzopyran-4-one core with multiple hydroxyl and methoxy substituents, which contribute to its diverse biological activities.
Uses
Used in Pharmaceutical Industry:
Methylophiopogonanone B is used as a bioactive compound for its potential therapeutic applications. It has been found to enhance protease activity, which is crucial for various cellular processes, including protein degradation and regulation of cellular signaling pathways. Additionally, it plays a role in regulating cytoskeleton remodeling, which is essential for maintaining cell shape, movement, and intracellular transport.
Used in Drug Development:
Methylophiopogonanone B can be employed as a lead compound in drug development, particularly for the treatment of diseases associated with impaired protease activity or cytoskeleton dysregulation. Its unique structure and biological properties make it a promising candidate for the development of novel therapeutic agents targeting various pathological conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 74805-91-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,8,0 and 5 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 74805-91:
(7*7)+(6*4)+(5*8)+(4*0)+(3*5)+(2*9)+(1*1)=147
147 % 10 = 7
So 74805-91-7 is a valid CAS Registry Number.
74805-91-7Relevant articles and documents
First synthesis of racemic methylophiopogonanone B and its inhibitory activity of hypoxia-inducible factor-1α
Fujii, Mikio,Egawa, Kiyoshi,Hirai, Yasuaki,Kondo, Masato,Akita, Hiroyuki,Nose, Kiyoshi,Toriizuka, Kazuo,Ida, Yoshiteru
, p. 207 - 212 (2009)
Methylophiopogonanone B, a constituent of Ophiopogonis tuber, found to be a potent inhibitor of hypoxia induced factor-1 α (HIF-1 α) activity, was synthesized from 2,4,6-trihydroxy-3,5-dimethylacetophenone in 57% yield. The synthetic methylophiopogonanone
