7472-54-0

Basic information

• Product Name: P-BENZANISIDIDE
• Synonyms: P-BENZANISIDIDE;N-(4-METHOXYPHENYL)BENZAMIDE;N-BENZOYL-P-ANISIDINE;4'-METHOXYBENZANILIDE;Benzamide, N-(4-methoxyphenyl)-;Benzamide, N-(p-methoxyphenyl)-;benzanisidide;P-BENZANISIDIDE 98+%
• CAS NO: 7472-54-0
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.26
• Mol File: 7472-54-0.mol
• Article Data: 320

Chemical Properties

• Melting Point: 155°C
• Boiling Point: 290.2 °C at 760 mmHg
• Flash Point: 129.3 °C
• Appearance: /
• Density: 1.181 g/cm³
• CAS DataBase Reference: P-BENZANISIDIDE(CAS DataBase Reference)
• NIST Chemistry Reference: P-BENZANISIDIDE(7472-54-0)
• EPA Substance Registry System: P-BENZANISIDIDE(7472-54-0)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 7472-54-0(Hazardous Substances Data)

Usage

General Description

P-Benzanisidide, also known as N-p-Tolylanthranilic acid, is a chemical compound that belongs to the group of aromatic amines. It is commonly used as a reagent in organic chemical reactions and is involved in the synthesis of various pharmaceutical compounds. P-Benzanisidide has been studied and utilized in the fields of drug development and pharmaceutical research due to its potential pharmacological activities. It has also been identified as a potential intermediate in the synthesis of other organic compounds and drugs. However,

Upstream product

• 98-88-4 benzoyl chloride 
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• 67-56-1 methanol 
• 83125-89-7 N-phenyl-N-(tosyloxy)benzamide 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 98610-70-9 1-(N,N-dibenzoyl)amino-5-bromomethyl-4-phenyl-1,2,3-triazole 
• 93-97-0 benzoic acid anhydride 
• 100-17-4 para-methoxynitrobenzene 
• 201230-82-2 carbon monoxide 
• 71-43-2 benzene 
• 5310-26-9 N-(4-methoxyphenyl)benzothioamide 
• 246872-21-9 N-{bis[3,5-bis(trifluoromethyl)phenyl]methylidene}(4-methoxyaniline) 
• 774-65-2 benzoic acid tert-butyl ester 
• 4231-62-3 1-benzoyl-1H-benzotriazole 

Downstream Products

• 106501-69-3 N-(4,4-dimethoxycyclohexa-2,5-dien-1-ylidene)benzamide 
• 106501-68-2 N-(1,4,4-Trimethoxy-cyclohexa-2,5-dienyl)-benzamide 
• 82791-59-1 6,7-Dimethoxy-2-(4-methoxy-phenyl)-1-phenyl-2H-isoquinolin-3-one 
• 108444-19-5 3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-isoindol-1-one 
• 38259-63-1 N-(4-methoxy-2-nitrophenyl)benzamide 
• 959217-28-8 6-methoxy-4-(methylthio)-2-phenylquinazoline 
• 27414-19-3 4-(6-methoxy-2-phenylquinazolin-4-yl)morpholine 
• 1192739-69-7 2-(6-methoxy-2-phenylquinazolin-4-yl)isoindoline-1,3-dione 
• 1192739-78-8 4-bromo-6-methoxy-2-phenylquinazoline 
• 1192739-71-1 6-methoxy-4-phenoxy-2-phenylquinazoline 
• 1201835-84-8 2-methoxy-9-phenylacridine 
• 23592-56-5 [2-(4-methoxyphenylamino)phenyl]phenylmethanone 
• 1026024-39-4 2-(4-methoxyphenyl)-3,4-dipropylisoquinolin-1(2H)-one 
• 1253388-48-5 2-(4-fluorophenyl)-3,4-diphenylisoquinolin-1(2H)-one 

Relevant articles and documents

Nickel-Catalyzed Cross-Electrophile Coupling between C(sp2)-F and C(sp2)-Cl Bonds by the Reaction of ortho-Fluoro-Aromatic Amides with Aryl Chlorides

Ni-catalyzed cross-electrophile coupling between C(sp2)-F bonds in ortho-fluoro-substituted aromatic amides and C(sp2)-Cl bonds in aryl chlorides in the presence of Zn as a reductant and LiOtBu as a base, and LiCl and ZnCl2 as additives is reported. The reaction displayed excellent functional group tolerance and a broad substrate scope. The reaction was also applicable to cross-electrophile coupling between C(sp2)-F and C(sp2)-O bonds in an aryl tosylate and a triflate derivative.

Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides

Herein we report a Ni-catalyzed reductive transamidation of conveniently available N-acyl benzotriazoles with alkyl, alkenyl, and aryl nitro compounds, which afforded various amides with good yields and a broad substrate scope. The same catalytic reaction conditions were also applicable for N-sulfonyl benzotriazoles, which could undergo smooth reductive coupling with nitroarenes and nitroalkanes to afford the corresponding sulfonamides.

IPr# - highly hindered, broadly applicable N-heterocyclic carbenes

IPr (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) represents the most important NHC (NHC = N-heterocyclic carbene) ligand throughout the field of homogeneous catalysis. Herein, we report the synthesis, catalytic activity, and full structural and electronic characterization of novel, sterically-bulky, easily-accessible NHC ligands based on the hash peralkylation concept, including IPr#, Np# and BIAN-IPr#. The new ligands have been commercialized in collaboration with Millipore Sigma: IPr#HCl, 915653; Np#HCl; 915912; BIAN-IPr#HCl, 916420, enabling broad access of the academic and industrial researchers to new ligands for reaction optimization and screening. In particular, the synthesis of IPr# hinges upon cost-effective, modular alkylation of aniline, an industrial chemical that is available in bulk. The generality of this approach in ligand design is demonstrated through facile synthesis of BIAN-IPr# and Np#, two ligands that differ in steric properties and N-wingtip arrangement. The broad activity in various cross-coupling reactions in an array of N-C, O-C, C-Cl, C-Br, C-S and C-H bond cross-couplings is demonstrated. The evaluation of steric, electron-donating and π-accepting properties as well as coordination chemistry to Au(i), Rh(i) and Pd(ii) is presented. Given the tremendous importance of NHC ligands in homogenous catalysis, we expect that this new class of NHCs will find rapid and widespread application.