7421-40-1

Basic information

• Product Name: Carbenoxolone disodium
• Synonyms: (3BETA-HYDROXY-11-OXOOLEAN-12-EN-30-OIC ACID 3-HEMISUCCINATE) DISODIUM SALT;CARBENOXOLONE DISODIUM SALT;CARBENOXOLONE SODIUM;18-beta-glycyrrhetinicacidhydrogensuccinate,disodiumsalt;20-beta)-3-bet;3-beta-hydroxy-11-oxoolean-12-en-30-oicacidhydrogensuccinate,disodiumsal;3-o-(beta-carboxypropionyl)-11-oxo-18-beta-olean-12-en-30-oicacid,disodium;disodiumglycyrrhetinylsuccina
• CAS NO: 7421-40-1
• Molecular Formula: C34H48Na2O7
• Molecular Weight: 614.72
• EINECS: 231-044-0
• Product Categories: Miscellaneous;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;OPTAFLEXX
• Mol File: 7421-40-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 687.4oC at 760 mmHg
• Flash Point: 211.6oC
• Appearance: /
• Vapor Pressure: 1.06E-20mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: Methanol (Slightly), Water (Slightly)
• PKA: pKa1 4.18; pKa2 5.52(at 25℃)
• Water Solubility: Soluble in water to 100 mM.
• Stability: Hygroscopic
• CAS DataBase Reference: Carbenoxolone disodium(CAS DataBase Reference)
• NIST Chemistry Reference: Carbenoxolone disodium(7421-40-1)
• EPA Substance Registry System: Carbenoxolone disodium(7421-40-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: RK0250000
• Hazardous Substances Data: 7421-40-1(Hazardous Substances Data)

Usage

Description

Carbenoxolone disodium is a synthetic derivative of glycyrrhetinic acid, a triterpenoid saponin found in licorice. It possesses anti-inflammatory and ulcer-healing properties, making it a versatile compound with applications in various fields.

Uses

Used in Pharmaceutical Industry:
Carbenoxolone disodium is used as an anti-inflammatory agent for its ability to reduce inflammation and promote healing in the digestive tract.
Used in Neuroscience Research:
Carbenoxolone disodium is used as a gap junction inhibitor, which helps researchers study the role of gap junctions in various neurological processes and diseases.
Used in Steroid Metabolism Research:
Carbenoxolone disodium is used as an inhibitor of the steroid dehydrogenase enzymes 11β-hydroxysteroid dehydrogenase (human) and 3α, 20β-hydroxysteroid dehydrogenase (bacterial), aiding in the investigation of steroid metabolism and its implications in various physiological and pathological conditions.
Used in Treatment of Digestive Tract Ulcers:
Carbenoxolone disodium is used as an antiulcerative agent for the treatment of peptic, mainly gastric, ulcers due to its ulcer-healing properties.
Used in Veterinary Medicine:
Carbenoxolone disodium is used as a beta-adrenergic agonist and growth stimulant in the livestock industry to promote growth and improve feed efficiency in animals.

Biological Activity

Glucocorticoid that inhibits 11 β -hydroxysteroid dehydrogenase (11-HSD) and blocks gap juntion communication.

references

[1]. jellinck ph, monder c, mcewen bs, et al. differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. j steroid biochem mol biol, 1993, 46(2): 209-213.[2]. sagar gd, larson dm. carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase a-dependent pathway. j cell biochem, 2006, 98(6): 1543-1551.

InChI:InChI=1/C34H50O7.2Na/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6;;/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40);;/q;2*+1/p-2/t21-,23-,24-,27+,30+,31-,32-,33+,34+;;/m0../s1