7417-21-2

Basic information

• Product Name: 2-(3,4-Dimethoxyphenyl)ethanol
• Synonyms: AKOS 222-31;3,4-DIMETHOXYPHENETHYL ALCOHOL;3,4-DIAMETHOXYBENZYL METHANOL;1-(2-Hydroxyethyl)-3,4-dimethoxybenzene;2-(3,4-Dimethoxyphenyl)ethanol;3,4-Dimethoxy-beta-phenethyl alcohol;3,4-Dimethoxyphenethanol;Benzeneethanol, 3,4-dimethoxy-
• CAS NO: 7417-21-2
• Molecular Formula: C₁₀H₁₄O₃
• Molecular Weight: 182.22
• EINECS: 231-032-5
• Product Categories: Benzhydrols, Benzyl & Special Alcohols
• Mol File: 7417-21-2.mol
• Article Data: 32

Chemical Properties

• Melting Point: 46-49 °C(lit.)
• Boiling Point: 172-174 °C17 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Light yellow/Crystalline Powder
• Density: 1.0966 (rough estimate)
• Vapor Pressure: 0.000702mmHg at 25°C
• Refractive Index: 1.4880 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.80±0.10(Predicted)
• BRN: 909742
• CAS DataBase Reference: 2-(3,4-Dimethoxyphenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-Dimethoxyphenyl)ethanol(7417-21-2)
• EPA Substance Registry System: 2-(3,4-Dimethoxyphenyl)ethanol(7417-21-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• Hazardous Substances Data: 7417-21-2(Hazardous Substances Data)

Usage

Description

2-(3,4-Dimethoxyphenyl)ethanol, also known as Homoveratryl alcohol, is a light yellow crystalline powder with unique chemical properties. It is a synthetic compound that has been utilized in various applications due to its specific characteristics.

Uses

Used in Chemical Research:
2-(3,4-Dimethoxyphenyl)ethanol is used as a model compound for studying the delignification mechanism of Mn(III)-substituted polyoxometalates (MSP). Its role in these studies aids in understanding the complex processes involved in the breakdown of lignin, which is a crucial component in the production of paper and biofuels.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, 2-(3,4-Dimethoxyphenyl)ethanol, given its structural similarity to various bioactive compounds, could potentially be used in the pharmaceutical industry as a starting material for the synthesis of drugs targeting specific receptors or enzymes.
Used in Material Science:
The light yellow crystalline nature of 2-(3,4-Dimethoxyphenyl)ethanol suggests that it may have applications in material science, particularly in the development of novel materials with specific optical or electronic properties.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 8, p. 266, 1960 DOI: 10.1248/cpb.8.266

InChI:InChI=1/C10H14O3/c1-12-9-4-3-8(5-6-11)7-10(9)13-2/h3-4,7,11H,5-6H2,1-2H3

Upstream product

• 61914-52-1 1-(3,4-dimethoxyphenyl)-5-hydroxydecan-3-one 
• 406215-61-0 1,2-dimethoxy-4-(2-tert-butyldimethylsiloxyethyl)benzene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 121-33-5 vanillin 
• 7786-61-0 3-methoxy-4-hydroxystyrene 
• 6380-23-0 3,4-dimethoxystyrene 
• 75-21-8 oxirane 
• 2859-78-1 4-Bromoveratrole 
• 91-16-7 1,2-dimethoxybenzene 
• 25379-88-8 2-(3,4-dihydroxyphenyl)acetic acid methyl ester 
• 102-32-9 3,4-dihydroxyphenylacetate 
• 14617-41-5 β-(3,4-Dimethoxy-phenyl)-ethyl-acetat 
• 67-56-1 methanol 
• 112693-26-2 C₃₇H₆₂O₁₇ 

Downstream Products

• 101585-34-6 phenyl-carbamic acid-(3,4-dimethoxy-phenethyl ester) 
• 75010-39-8 1-(3,4-dimethoxyphenyl)-2-(p-toluenesulfonyloxy)ethane 
• 27160-08-3 2-(3,4-dimethoxyphenyl)-ethylchloride 
• 220556-03-6 4-(2-bromo-ethyl)-pyrocatechol 
• 69690-12-6 4-(2-iodoethyl)benzene-1,2-diol 
• 19084-86-7 4-(3,4-dimethoxy-phenethyloxy)-1H-benzo[d][1,2]oxazine 
• 86106-20-9 3-<2-(3,4-dimethoxyphenyl)ethyl>thiazolidine-2,4-dione 
• 85002-64-8 1,2-Dimethoxy-4-[2-(4-nitro-phenoxy)-ethyl]-benzene 
• 92774-37-3 6,7-dimethoxy-1-(3-methoxyphenyl)isochroman 
• 327621-46-5 2-[2-(3,4-dimethoxyphenyl)ethyl]cyclohexane-1,3-one 
• 503114-36-1 methyl N-3,4-dimethoxyphenethyl-3',4'-bis-(3,4-dimethoxyphenyl)pyrrole-2-carboxylate 
• 503114-37-2 N-3,4-dimethoxyphenethyl-3',4'-bis-(3,4-dimethoxyphenyl)pyrrole-2-carboxylic acid 
• 266674-78-6 1-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)ethyl]-7,8-dimethoxy-4-oxo-3H-[1]benzopyrano[3,4-b]pyrrole-4-one 
• 846601-44-3 3-(3,4-dimethoxyphenyl)-2-{[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]methylamino}propionitrile 

Relevant articles and documents

Biotransformation of pungent constituents from ginger (Zingiber officinale Roscoe) by Colletotrichum gloeosporioides yields oxidative ortho–ortho coupling products

This work investigated the biotransformation of ginger constituents (zingerone, [6]-shogaol, [6]-gingerol, and methyl-[6]-gingerol) by the pathogenic fungus Colletotrichum gloeosporioides. Experiments were carried out with and without deuterium-labelled compounds. The product metabolites were analyzed by liquid chromatography coupled to tandem mass spectrometry and liquid chromatography solid phase extraction-nuclear magnetic resonance. Substrates supplied to the fungus were incorporated into metabolic pathways mostly by oxidation reactions, including aromatic carbon–carbon coupling. Zingerone and [6]-gingerol biotransformation products included biphenol dimers. A biodegradation pathway for biphenol formation was proposed based on the presence of the intermediate 4-(2-hydroxyethyl)-2-methoxyphenol, commonly identified from [6]-gingerol and [6]-shogaol biodegradation. This intermediate likely originates from a Baeyer–Villiger reaction followed by hydrolysis. The C–C coupling of molecules could result in phenolic oxidative ortho–ortho coupling, suggesting that biphenol dimers are products of C. gloeosporioides laccase catalysis.

Tetrabenazine intermediate as well as synthesis method and application thereof as, well as intermediate product for synthesis (by machine translation)

The invention belongs to, the field of drug synthesis, and particularly relates to a butanaphenazine, intermediate and a synthesis method, thereof, as well as a synthesis: method 3,4 - thereof; and, 6,7 . (by machine translation)

BIOISPIRED PROTEASOME ACTIVATORS WITH ANTIAGEING ACTIVITY

The present invention relates to novel bio-inspired hybrid compounds of formula I which act as proteasome activators and exhibit anti-ageing activity, as well as methods for their synthesis. These hybrid compounds combine the structural features of hydroxytyrosol and the natural antioxidant vitamin E or its bioisosteres in one molecular scaffold. The compounds of formula I, which include structural proteasome activators (activation by stereochemical interaction), can be used in the production of anti-ageing products, such as cosmetic preparations. Additionally, they can be used in conditions and diseases where the proteasome is down-regulated, as well as proteasome-activation control compounds.