73855-59-1 Usage
Description
(5E)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one is a complex chemical compound that features a thiazolidine ring fused with an indole moiety. It is a type of thiazolidinone, which is a heterocyclic compound containing sulfur. This particular compound is distinguished by its unique molecular structure and holds potential for various pharmaceutical applications due to its intriguing biological activities. (5E)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one's classification within the thiazolidinone family suggests it may possess properties that are beneficial in the development of treatments for conditions such as diabetes, inflammation, and cancer.
Uses
Used in Pharmaceutical Research:
(5E)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one is utilized as a subject of pharmaceutical research for its potential as an antidiabetic, anti-inflammatory, and anticancer agent. Its unique molecular arrangement and the biological activities associated with thiazolidinones make it a promising candidate for the development of new drugs.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (5E)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one serves as a compound of interest for the exploration of its pharmacological properties. The study of its interactions with biological targets could lead to insights that are valuable for the creation of novel therapeutic agents.
Used in Drug Development:
(5E)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one is used in drug development as a potential lead compound. Its structure may be optimized and modified to enhance its therapeutic effects and to improve its pharmacokinetic and pharmacodynamic profiles, which are crucial for its efficacy and safety in clinical applications.
Used in Chemical Synthesis:
In chemical synthesis, (5E)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one may be employed as a building block or a precursor in the synthesis of more complex molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 73855-59-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,8,5 and 5 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 73855-59:
(7*7)+(6*3)+(5*8)+(4*5)+(3*5)+(2*5)+(1*9)=161
161 % 10 = 1
So 73855-59-1 is a valid CAS Registry Number.
73855-59-1Relevant articles and documents
Biosynthesis of Chuangxinmycin Featuring a Deubiquitinase-like Sulfurtransferase
Bian, Xiaoying,Cheng, Fangyuan,Du, Lei,Geng, Ce,Guo, Jiawei,Lan, Haidong,Li, Shengying,Li, Yuezhong,Sang, Moli,Shen, Yuemao,Tang, Ya-Jie,Wang, Sheng,Xu, Xiaokun,Yang, Chaofan,Yang, Fan,You, Cai,Zhang, Wei,Zhang, Xingwang,Zhang, Youming
supporting information, p. 24418 - 24423 (2021/10/12)
The knowledge on sulfur incorporation mechanism involved in sulfur-containing molecule biosynthesis remains limited. Chuangxinmycin is a sulfur-containing antibiotic with a unique thiopyrano[4,3,2-cd]indole (TPI) skeleton and selective inhibitory activity against bacterial tryptophanyl-tRNA synthetase. Despite the previously reported biosynthetic gene clusters and the recent functional characterization of a P450 enzyme responsible for C?S bond formation, the enzymatic mechanism for sulfur incorporation remains unknown. Here, we resolve this central biosynthetic problem by in vitro biochemical characterization of the key enzymes and reconstitute the TPI skeleton in a one-pot enzymatic reaction. We reveal that the JAMM/MPN+ protein Cxm3 functions as a deubiquitinase-like sulfurtransferase to catalyze a non-classical sulfur-transfer reaction by interacting with the ubiquitin-like sulfur carrier protein Cxm4GG. This finding adds a new mechanism for sulfurtransferase in nature.
