73719-79-6

Basic information

• Product Name: 4-phenacylthiouridine
• Synonyms: 4-phenacylthiouridine
• CAS NO: 73719-79-6
• Molecular Weight: 378.406
• Mol File: 73719-79-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-phenacylthiouridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenacylthiouridine(73719-79-6)
• EPA Substance Registry System: 4-phenacylthiouridine(73719-79-6)

Safety Data

• Hazardous Substances Data: 73719-79-6(Hazardous Substances Data)

Upstream product

• 13957-31-8 4-thiouridine 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 73719-83-2 1-β-D-ribofuranosyl-4-phenacylidene-2-(3H)-pyrimidone 

Relevant articles and documents

Introduction of Carbon Substituents into Pyrimidine and Purine Nucleosides by Sulfur Extrusion (Nucleosides and Nucleotides. XXX)

Treatment of 4-thiouridine with phenacyl bromide, bromoacetone, and ethyl bromoacetate gave the corresponding 4-thioalkylcarbonyl derivatives.The sulfur extrusion reactions of these compounds afforded ribosides of 4-phenylacylidene-2(3H)-pyrimidone, 4-acetonylidene-2(3H)-pyrimidone, and 2-pyrimidone-4-acetic ester, respectively.The ease of sulfur extrusion depends on the electron-withdrawing ability of the carbonyl group attached to the 4-S-methylene group.Sulfur extrusion reactions starting from 6-thioinosine similarly gave the ribofuranosides of 6-phenacylpurine and 6-acetopurine.These purine ribosides exist mainly as the enol form rather than the keto form.Keywords- sulfur extrusion reaction; thionucleosides; nucleosides; triphenylphosphine; UV; NMR