73334-07-3Relevant articles and documents
Preparation method and application of iopromide intermediate (by machine translation)
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, (2020/07/24)
The invention relates to a preparation method of an iopromide intermediate and an application thereof in preparation of iopromide. The method comprises the following steps: compound VI compound is subjected to reduction reaction under the action of Raney nickel/hydrazine hydrate to obtain the compound V compound. The reaction is carried out under normal pressure, the operation is simple and safe, the generated intermediate impurities are less, and the reaction is more suitable for industrial production. The method is used for preparing iopromide, can avoid the generation of a diacylated by-product, can effectively reduce the generation of by-products in the preparation process, can be easily separated and purified, and can obtain high-purity iopromide with high yield. (by machine translation)
A method for preparing [...]
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Paragraph 0025; 0048; 0049, (2018/12/13)
The present invention relates to an X-ray contrast agent iopromide preparation method. According to the method, 3-methoxy acetyl-5-(2,3-dihydroxy-N-methyl-n-propyl-carbamoyl)-2,4,6-triiodobenzoic acid (4) is introduced as an intermediate, the used raw material is cheap and easy to obtain, the experiment operation is relatively simple, the reaction condition is mild, and the product purity is qualified.
5 - Amino - 2, 4, 6 - damaged by phthalic acid derivatives and its salt, hydrate or solvate
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Paragraph 0074; 0124; 0125, (2018/12/13)
The invention relates to a 5-amino-2,4,6-triiodo m-phthalic acid derivative as shown in the general formula I and salt, hydrate or solvate thereof, wherein substituent groups R1, R2, R3 and R4 are as defined in the specification. The invention also relates to a compound as shown in the general formula I and also relates to an application of the compound and its salt, hydrate or solvate in the preparation of iopromide.