7329-52-4 Usage
Description
2-Methoxyphenol-3,4,5,6-D4 is an isotopically labeled research compound with the chemical formula C7D4H8O. It is a deuterated derivative of 2-methoxyphenol, which is a type of phenolic compound. The presence of deuterium (D) atoms in its structure makes it a valuable tool for various research applications, particularly in the field of chemistry and biochemistry.
Uses
Used in Chemical Reaction Studies:
2-Methoxyphenol-3,4,5,6-D4 is used as a labeled compound in chemical reaction studies to investigate reaction mechanisms, kinetics, and intermediates. The incorporation of deuterium atoms allows researchers to track the behavior of the molecule during reactions, providing insights into the reaction pathways and helping to elucidate the underlying chemistry.
Used in Biochemical Research:
In biochemical research, 2-Methoxyphenol-3,4,5,6-D4 can be employed as a stable isotope tracer to study the metabolism and biotransformation of phenolic compounds in biological systems. The use of deuterated compounds enables the differentiation between endogenous and exogenous compounds, facilitating the analysis of metabolic pathways and the identification of metabolic products.
Used in Analytical Chemistry:
2-Methoxyphenol-3,4,5,6-D4 is utilized as an internal standard in analytical chemistry for the accurate quantification of phenolic compounds in complex samples. The presence of deuterium atoms provides a distinct mass difference between the labeled compound and the native compound, allowing for precise measurement and quantification using techniques such as mass spectrometry.
Used in Environmental Studies:
In environmental studies, 2-Methoxyphenol-3,4,5,6-D4 can be applied as a tracer to investigate the fate and transport of phenolic compounds in the environment. The use of isotopically labeled compounds helps to monitor the behavior of these compounds in various environmental matrices, such as soil, water, and air, and can provide valuable information on their degradation, sorption, and bioavailability.
Used in Pharmaceutical Development:
2-Methoxyphenol-3,4,5,6-D4 can be employed in pharmaceutical development as a labeled analog of 2-methoxyphenol for the study of drug metabolism, pharmacokinetics, and drug-drug interactions. The use of deuterated compounds can help to identify potential metabolic pathways and the formation of metabolites, which is crucial for the optimization of drug candidates and the assessment of their safety and efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 7329-52-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,3,2 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 7329-52:
(6*7)+(5*3)+(4*2)+(3*9)+(2*5)+(1*2)=104
104 % 10 = 4
So 7329-52-4 is a valid CAS Registry Number.
7329-52-4Relevant articles and documents
Evaluation of the α-phenylvinyl cation as a chemical ionization reagent for the differentiation of isomeric substituted phenols in an ITMS
Begala, Michela
, p. 693 - 702 (2015)
Ion-molecule reactions between the α-phenylvinyl cation and isomeric naturally occurring phenols were investigated using a quadruple ion trap mass spectrometer. The α-phenylvinyl cation m/z 103, generated by chemical ionization from phenylacetylene, reacts with neutral aromatic compounds to form the characteristic species: [M + 103]+ adduct ions and the trans-vinylating product ions [M + 25]+, which correspond to [M + 103]+ adduct after the loss of benzene. Isomeric differentiation of several ring-substituted phenols was achieved by using collision-induced dissociation of the [M + 103]+ adduct ions. This method also showed to be effective in the differentiation of 4-ethylguaiacol from one of its structural isomers that displays identical EI and EI/MS/MS spectra. The effects of gas-phase alkylation with phenylvinyl cation on the dissociation behavior were examined using mass spectrometryn and labeled derivatives.
Aqueous Oxidations Started by TiO2 Photoinduced Holes Can Be a Rate-Determining Step
Gong, Yuanzheng,Yang, Chun,Ji, Hongwei,Chen, Chuncheng,Ma, Wanhong,Zhao, Jincai
supporting information, p. 2048 - 2051 (2017/08/23)
In aqueous TiO2 photocatalytic hydroxylation of weakly polar aromatics, a series of inverse H/D KIEs of 0.7–0.8 were observed, which is different than the normal H/D kinetic isotope effects (KIEs) usually observed for polar aromatics. This result indicated that the oxidation started by photo-induced hvb + can be the rate-determining step.
Microwave-assisted deuterium exchange: The convenient preparation of isotopically labelled analogues for stable isotope dilution analysis of volatile wine phenols
Crump, Anna M.,Sefton, Mark A.,Wilkinson, Kerry L.
, p. 261 - 263 (2014/06/09)
This study reports the convenient, low cost, one-step synthesis of labelled analogues of six volatile phenols, guaiacol, 4-methylguaiacol, 4-ethylguaiacol, 4-ethylphenol, eugenol and vanillin, using microwave-assisted deuterium exchange, for use as intern
