72804-96-7 Usage
Description
O-Diphenylphosphinylhydroxylamine is a light yellow or white powder solid that serves as a general reagent for electrophilic C-amination. It is known for its ability to aminate a variety of stable carbanions and Grignard reagents, making it a valuable compound in the field of organic chemistry.
Uses
Used in Organic Synthesis:
O-Diphenylphosphinylhydroxylamine is used as an efficient reagent for the direct conversion of aldehydes to nitriles, even in the presence of alcohol, ketone, ester, or amine functionality. This makes it a versatile tool in the synthesis of various organic compounds.
Used in the Preparation of Trans-Acylaziridines and Aldohydrazones:
O-Diphenylphosphinylhydroxylamine is used as a versatile reactant in the synthetic preparation of trans-acylaziridines and aldohydrazones, which are important intermediates in the synthesis of various pharmaceuticals and biologically active compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, O-Diphenylphosphinylhydroxylamine is used as a key intermediate in the synthesis of various drugs, particularly those involving the formation of amide or amine groups.
Used in Chemical Research:
O-Diphenylphosphinylhydroxylamine is also used as a research tool in the development of new synthetic methods and the study of reaction mechanisms in organic chemistry. Its ability to aminate various carbanions and Grignard reagents makes it a valuable compound for exploring new reaction pathways and improving existing synthetic processes.
Synthesis Reference(s)
Tetrahedron Letters, 23, p. 3835, 1982 DOI: 10.1016/S0040-4039(00)87720-5
Check Digit Verification of cas no
The CAS Registry Mumber 72804-96-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,8,0 and 4 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 72804-96:
(7*7)+(6*2)+(5*8)+(4*0)+(3*4)+(2*9)+(1*6)=137
137 % 10 = 7
So 72804-96-7 is a valid CAS Registry Number.
72804-96-7Relevant articles and documents
An improved preparation of O-(Diphenylphosphinyl)hydroxylamine
Laulhe, Sebastien,Nantz, Michael H.
, p. 475 - 476 (2011)
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Scalable preparation of o-(Diphenylphosphinyl) hydroxylamine (DPPH)
Benkovics, Tamas,Hughes, Gregory J.,Neel, Andrew J.,Zhao, Ralph
, p. 54 - 65 (2020/06/03)
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PDE9 INHIBITORS WITH IMIDAZO TRIAZINONE BACKBONE AND IMIDAZO PYRAZINONE BACKBONE FOR TREATMENT OF PERIPHERAL DISEASES
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Page/Page column 57, (2017/02/09)
The present invention relates to PDE9 inhibitors and their use for treatment of benign prostate hyperplasia and sickle cell disease.
