72537-17-8 Usage
Description
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine is a halogenated pyridine derivative that serves as a fluorinated building block in chemical synthesis. It is characterized by the presence of a chlorine atom at the 3-position, a fluorine atom at the 2-position, and a trifluoromethyl group at the 5-position on the pyridine ring. 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE is involved in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine, which is an important intermediate in the production of various pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Industry:
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structural features, including the presence of halogen atoms and the trifluoromethyl group, make it a valuable building block for the development of new drugs with improved pharmacological properties.
Used in Agrochemical Industry:
In the agrochemical industry, 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine is utilized as a precursor for the synthesis of novel agrochemicals with enhanced biological activity. Its incorporation into the molecular structure of these compounds can lead to improved pest control and crop protection.
Used in Organic Synthesis:
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine is also employed as a versatile building block in organic synthesis for the preparation of a wide range of fluorinated heterocyclic compounds. Its reactivity and functional group compatibility make it a valuable component in the synthesis of complex organic molecules with potential applications in various fields, such as materials science, medicinal chemistry, and chemical biology.
Check Digit Verification of cas no
The CAS Registry Mumber 72537-17-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,5,3 and 7 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 72537-17:
(7*7)+(6*2)+(5*5)+(4*3)+(3*7)+(2*1)+(1*7)=128
128 % 10 = 8
So 72537-17-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H2ClF4N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H
72537-17-8Relevant articles and documents
Bitopertin synthetic method and intermediate
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Paragraph 0061-0063, (2018/03/26)
The present invention discloses a new synthesis method and intermediates of Bitopertin. According to the Bitopertin synthesis method, 5-methylsulfonyl-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]benzoic acid is adopted as a raw material, and continuous multi-step operations such as chlorination, acylation, deprotection, condensation and re-crystallization are subjected to performed to obtain the Bitopertin, wherein the intermediates in each step do not require further purification, and the total yield can achieve more than or equal to 80%.
A 2 - cyano - 3 - chloro - 5 - trifluoro methyl pyridine synthesis method (by machine translation)
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Paragraph 0032; 0033, (2017/11/04)
The invention discloses a 2 - cyano - 3 - chloro - 5 - trifluoro methyl pyridine synthesis method, which belongs to the technical field of organic synthesis. The method includes the steps of: (1) to 2, 3 - dichloro - 5 - trifluoro methyl pyridine as raw material, in the solvent system is added in the catalyst, by fluorination synthesis of 2 - fluoro - 3 - chloro - 5 - trifluoro methyl pyridine, (2) in the step 1 of the 2 - fluoro - 3 - chloro - 5 - trifluoro methyl pyrrole cyanide reagent carbonitriding after adding, after the water washing, after the distillation, shall be 2 - cyano - 3 - chloro - 5 - trifluoro methyl pyridine. The purity of the product can reach 99.5%, the yield can be 90%, the reaction condition during the mild, easy to operate, and is suitable for large-scale production. (by machine translation)