72411-52-0

Basic information

• Product Name: 5-(4-FLUOROPHENYL)-2H-PYRAZOL-3-YLAMINE
• Synonyms: TIMTEC-BB SBB009542;5-Amino-3-(4-fluorophenyl)-1H-pyrazole;5-(4-FLUOROPHENYL)-2H-PYRAZOL-3-YLAMINE 98%;5-(4-FLUOROPHENYL)-1H-PYRAZOL-3-AMINE;3-Amino-5-(4-fluorophenyl)-1H-pyrazole;3-(4-fluorophenyl)-1H-pyrazol-5-amine (en);1H-Pyrazol-3-aMine,5-(4-fluorophenyl)-;CHEMBRDG-BB 4002019
• CAS NO: 72411-52-0
• Molecular Formula: C₉H₈FN₃
• Molecular Weight: 177.18
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrazoles
• Mol File: 72411-52-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 119-123 °C(lit.)
• Boiling Point: 435.4 °C at 760 mmHg
• Flash Point: 217.1 °C
• Appearance: /
• Density: 1.334 g/cm³
• Vapor Pressure: 8.77E-08mmHg at 25°C
• Refractive Index: 1.636
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 14.32±0.10(Predicted)
• CAS DataBase Reference: 5-(4-FLUOROPHENYL)-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-FLUOROPHENYL)-2H-PYRAZOL-3-YLAMINE(72411-52-0)
• EPA Substance Registry System: 5-(4-FLUOROPHENYL)-2H-PYRAZOL-3-YLAMINE(72411-52-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 72411-52-0(Hazardous Substances Data)

Usage

General Description

5-(4-FLUOROPHENYL)-2H-PYRAZOL-3-YLAMINE is a chemical compound that belongs to the pyrazole class of organic compounds. It is an amine derivative with a pyrazole structure, containing a 4-fluorophenyl group. 5-(4-FLUOROPHENYL)-2H-PYRAZOL-3-YLAMINE has potential applications in pharmaceutical research, particularly in the development of new drugs targeting various biological processes. It may also have potential uses in chemical synthesis and as a building block for the creation of other organic compounds. The exact properties and uses of this chemical may vary depending on its specific application and context.

InChI:InChI=1/C9H8FN3/c10-7-3-1-6(2-4-7)8-5-9(11)13-12-8/h1-5H,(H3,11,12,13)

Upstream product

• 575433-43-1 3-(4-fluorophenyl)-2-propynenitrile 
• 4640-67-9 3-(4-fluorophenyl)-3-oxopropionitrile 
• 459-57-4 4-fluorobenzaldehyde 
• 403-33-8 methyl 4-flurobenzoate 
• 456-22-4 4-Fluorobenzoic acid 

Downstream Products

• 74073-50-0 3-(4-fluoro-phenyl)-4-pentafluorophenyl-4,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7-one 
• 1363184-99-9 3-(4-fluorophenyl)-4-hydroxy-4-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one 

Relevant articles and documents

Synthesis of Pyrazole Compounds by Using Sonication Method

A simple method for the synthesis of pyrazoles derivatives carried out by cyclization of cyanide with hydrazine hydrate by using sonication method. All the prepared compounds were characterized by 1H, 13C NMR and IR Spectroscopy.

Modular synthesis and antiproliferative activity of new dihydro-1H-pyrazolo[1,3-b]pyridine embelin derivatives

A set of new dihydro-1H-pyrazolo[1,3-b]pyridine and pyrazolo[1,3-b]pyridine embelin derivatives was synthesized through a multicomponent reaction from natural embelin, 3-substituted-5-aminopyrazoles and aldehydes. The synthesized compounds were evaluated against three hematologic tumor cell lines, HEL (acute erythroid leukemia), K-562 (chronic myeloid leukemia) and HL-60 (acute myeloid leukemia), and five breast cancer cell lines (SKBR3, MCF-7, MDA-MB-231, BT-549, HS-578T). The primate non-malignant kidney Vero cell line was used as the control of cytotoxicity. From the obtained results, some structure–activity relationships were out-lined. Furthermore, in silico prediction of physicochemical properties and ADME parameters were determined for the derivatives with the best antiproliferative values.

Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation

A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls, heterocycles, and alkyl groups.