72210-07-2

Basic information

• Product Name: Benzenesulfonamide, 4-methyl-N,N-bis(phenylmethyl)-
• CAS NO: 72210-07-2
• Molecular Formula: C21H21NO2S
• Molecular Weight: 351.469
• Mol File: 72210-07-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 4-methyl-N,N-bis(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 4-methyl-N,N-bis(phenylmethyl)-(72210-07-2)
• EPA Substance Registry System: Benzenesulfonamide, 4-methyl-N,N-bis(phenylmethyl)-(72210-07-2)

Safety Data

• Hazardous Substances Data: 72210-07-2(Hazardous Substances Data)

Upstream product

• 103-49-1 dibenzylamine 
• 1576-37-0 N-benzyl-p-toluenesulfonamide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 100-51-6 benzyl alcohol 
• 70-55-3 toluene-4-sulfonamide 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 98-59-9 p-toluenesulfonyl chloride 
• 20992-37-4 ethyl (2E)-cyano({[(4-methylphenyl)sulfonyl]oxy}imino)acetate 
• 100-46-9 benzylamine 
• 100-52-7 benzaldehyde 
• 620-40-6 tribenzylamine 

Downstream Products

• 103-49-1 dibenzylamine 

Relevant articles and documents

Mitsunobu Reaction Using Basic Amines as Pronucleophiles

A novel protocol for extending the scope of the Mitsunobu reaction to include amine nucleophiles to form C-N bonds through the utilization of N-heterocyclic phosphine-butane (NHP-butane) has been developed. Both aliphatic alcohols and benzyl alcohols are suitable substrates for C-N bond construction. Various acidic nucleophiles such as benzoic acids, phenols, thiophenol, and secondary sulfonamide also provide the desired products of esters, ethers, thioether, and tertiary sulfonamide with 43-93% yields. Importantly, C-N bond-containing pharmaceuticals, Piribedil and Cinnarizine, have been synthesized in one step from the commercial amines under this Mitsunobu reaction system.

Oxidation-Reduction Condensation of Diazaphosphites for Carbon-Heteroatom Bond Formation Based on Mitsunobu Mechanism

An efficient oxidation-reduction condensation reaction of diazaphosphites with various nonacidic pronucleophiles in the presence of DIAD as a weak oxidant has been developed for carbon-heteroatom bond formation. This mild process affords structurally diverse tertiary amines, secondary amines, esters, ethers, and thioethers in moderate to excellent yields. The selective synthesis of secondary amines from primary amines has been achieved. Importantly, a practical application to the synthesis of antiparkinsonian agent piribedil has been demonstrated.

Iodine-catalyzed expeditious synthesis of sulfonamides from sulfonyl hydrazides and amines

A new synthesis of sulfonamides has been developed via an iodine-catalyzed sulfonylation of amines with arylsulfonyl hydrazides. This metal-free strategy employs readily accessible and easy to handle starting materials, catalysts and oxidants, and can be easily conducted under mild conditions, providing a convenient access to a wide range of sulfonamides in moderate to excellent yields within a short reaction time.