7195-78-0Relevant articles and documents
Design and synthesis of 5-chloro-2-hydroxy-3-triazolylbenzoic acids as HIV integrase inhibitors
Chen, Jie,Liu, Cheng-Fu,Yang, Cheng-Wen,Zeng, Cheng-Chu,Liu, Wei,Hu, Li-Ming
, p. 2950 - 2959 (2015)
A series of potential HIV-1 integrase inhibitors based on 5-chloro-2-hydroxy-3-triazolylbenzoic acid scaffold was designed and synthesized. Some of these compounds exhibit potent inhibitory activities at micromolar concentrations against HIV-1 integrase i
Development of a Phase-Transfer-Catalyzed, [2,3]-Wittig Rearrangement
Denmark, Scott E.,Cullen, Lindsey R.
, p. 11818 - 11848 (2015/12/11)
An investigation into the use of phase-transfer catalysis for the [2,3]-sigmatropic rearrangement of allyloxy carbonyl compounds is described. Initial studies focused on identifying viable substrate classes that would undergo selective [2,3]-rearrangement under phase-transfer catalysis. Under certain conditions, the [2,3]-sigmatropic rearrangement of allyloxy carbonyl compounds takes place in the presence of a phase-transfer agent, providing a rare example of a phase-transfer-catalyzed unimolecular reaction. In the course of this investigation, it was found that catalysis is dependent on several variables including base concentration, catalyst structure, and substrate lipophilicity. Preliminary testing of chiral, nonracemic phase-transfer catalysts has shown promising levels of enantioselectivity for future development.
Synthesis and Enzymatic Evaluation of Conformationally Defined Carnitine Analogs
Brouillette, Wayne J.,Saeed, Ashraf,Abuelyaman, Ahmed,Hutchison, Tracy L.,Wolkowicz, Paul E.,McMillin, Jeanie B.
, p. 4297 - 4303 (2007/10/02)
Carnitine (1, 3-hydroxy-4-trimethylammoniobutyrate) is essential as a donor and acceptor of acyl groups in cellular metabolism.The major solution conformation of carnitine about C3-C4 contains the gauche reletionship between the trimethylammonium and hydr